Cerebral Cortex 1993; 3:148-162
© Oxford University Press 1993
research-article |
Comparison of Intrinsic Connectivity in Different Areas of Macaque Monkey Cerebral Cortex
1Department of Psychiatry, University of Pittsburgh Pittsburgh, Pennsylvania, 15261, 2Department of Neurobiology, Anatomy and Cell Science, University of Pittsburgh Pittsburgh, Pennsylvania, 15261, 3Department of Visual Science, Institute of Ophthalmology, University of London London EC1V 9EL, United Kingdom
We have used small injections of biocytin to label and compare patterns of intreareal, laterally spreading projections of pyramidal neurons in a number of areas of macaque monkey cerebral cortex. In visual areas (V1, V2, and V4), somatosensory areas (3b, 1, and 2), and motor area 4, a punctate discontinuous pattern of connections is made from 200-µm-diameter biocytin injections in the superficial layers. In prefrontal cortex (areas 9 and 46), stripe-like connectivity patterns are observed. In all areas of cortex examined, the width of the terminal-free gaps is closely scaled to the average diameter of terminal patches, or width of terminal stripes. In addition, both patch and gap dimensions match the average lateral spread of the dendritic field of single pyramidal neurons in the superficial layers of the same cortical region. These architectural features of the connectional mosaics are constant despite a twofold difference in scale across cortical areas and different species. They therefore appear to be fundamental features of cortical organization. A model is offered in which local circuit inhibitory "basket" interneurons, activated at the same time as excitatory pyramidal neurons, could veto pyramidal neuron connections within either circular or stripe-like domains; this could lead to the formation of the pattern of lateral connections observed in this study, and provides a framework for further theoretical studies of cerebral cortex function.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  P. Broser, V. Grinevich, P. Osten, B. Sakmann, and D. J. Wallace Critical Period Plasticity of Axonal Arbors of Layer 2/3 Pyramidal Neurons in Rat Somatosensory Cortex: Layer-Specific Reduction of Projections into Deprived Cortical Columns Cereb Cortex, July 1, 2008; 18(7): 1588 - 1603. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Ahmed, A. Hanazawa, C. Undeman, D. Eriksson, S. Valentiniene, and P. E. Roland Cortical Dynamics Subserving Visual Apparent Motion Cereb Cortex, March 28, 2008; (2008) bhn038v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Matsuzaki, G. C. R. Ellis-Davies, and H. Kasai Three-Dimensional Mapping of Unitary Synaptic Connections by Two-Photon Macro Photolysis of Caged Glutamate J Neurophysiol, March 1, 2008; 99(3): 1535 - 1544. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Tardif, A. Probst, and S. Clarke Laminar Specificity of Intrinsic Connections in Broca's Area Cereb Cortex, December 1, 2007; 17(12): 2949 - 2960. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Binzegger, R. J. Douglas, and K. A. C. Martin Stereotypical Bouton Clustering of Individual Neurons in Cat Primary Visual Cortex J. Neurosci., November 7, 2007; 27(45): 12242 - 12254. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. P. Georgopoulos, H. Merchant, T. Naselaris, and B. Amirikian Mapping of the preferred direction in the motor cortex PNAS, June 26, 2007; 104(26): 11068 - 11072. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Schuz, D. Chaimow, D. Liewald, and M. Dortenman Quantitative Aspects of Corticocortical Connections: A Tracer Study in the Mouse Cereb Cortex, October 1, 2006; 16(10): 1474 - 1486. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. D. Van Hooser, J. A. Heimel, S. Chung, and S. B. Nelson Lack of patchy horizontal connectivity in primary visual cortex of a mammal without orientation maps. J. Neurosci., July 19, 2006; 26(29): 7680 - 7692. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. A. Koene and M. E. Hasselmo An Integrate-and-fire Model of Prefrontal Cortex Neuronal Activity during Performance of Goal-directed Decision Making Cereb Cortex, December 1, 2005; 15(12): 1964 - 1981. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Tanigawa, Q. Wang, and I. Fujita Organization of Horizontal Axons in the Inferior Temporal Cortex and Primary Visual Cortex of the Macaque Monkey Cereb Cortex, December 1, 2005; 15(12): 1887 - 1899. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Shinomoto, Y. Miyazaki, H. Tamura, and I. Fujita Regional and Laminar Differences in In Vivo Firing Patterns of Primate Cortical Neurons J Neurophysiol, July 1, 2005; 94(1): 567 - 575. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. K. Esser, S. L. Hill, and G. Tononi Modeling the Effects of Transcranial Magnetic Stimulation on Cortical Circuits J Neurophysiol, July 1, 2005; 94(1): 622 - 639. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. N. Elston, R. Benavides-Piccione, and J. DeFelipe A Study of Pyramidal Cell Structure in the Cingulate Cortex of the Macaque Monkey with Comparative Notes on Inferotemporal and Primary Visual Cortex Cereb Cortex, January 1, 2005; 15(1): 64 - 73. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Watts and A. M. Thomson Excitatory and inhibitory connections show selectivity in the neocortex J. Physiol., January 1, 2005; 562(1): 89 - 97. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Wang, M. Toledo-Rodriguez, A. Gupta, C. Wu, G. Silberberg, J. Luo, and H. Markram Anatomical, physiological and molecular properties of Martinotti cells in the somatosensory cortex of the juvenile rat J. Physiol., November 15, 2004; 561(1): 65 - 90. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Butovas and C. Schwarz Spatiotemporal Effects of Microstimulation in Rat Neocortex: A Parametric Study Using Multielectrode Recordings J Neurophysiol, November 1, 2003; 90(5): 3024 - 3039. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. N. Elston Cortex, Cognition and the Cell: New Insights into the Pyramidal Neuron and Prefrontal Function Cereb Cortex, November 1, 2003; 13(11): 1124 - 1138. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Thomson and A. P. Bannister Interlaminar Connections in the Neocortex Cereb Cortex, January 1, 2003; 13(1): 5 - 14. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. S. Lund, A. Angelucci, and P. C. Bressloff Anatomical Substrates for Functional Columns in Macaque Monkey Primary Visual Cortex Cereb Cortex, January 1, 2003; 13(1): 15 - 24. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Constantinidis and P. S. Goldman-Rakic Correlated Discharges Among Putative Pyramidal Neurons and Interneurons in the Primate Prefrontal Cortex J Neurophysiol, December 1, 2002; 88(6): 3487 - 3497. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. N. Elston and K. S. Rockland The Pyramidal Cell of the Sensorimotor Cortex of the Macaque Monkey: Phenotypic Variation Cereb Cortex, October 1, 2002; 12(10): 1071 - 1078. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Thomson, D. C. West, Y. Wang, and A. P. Bannister Synaptic Connections and Small Circuits Involving Excitatory and Inhibitory Neurons in Layers 2-5 of Adult Rat and Cat Neocortex: Triple Intracellular Recordings and Biocytin Labelling In Vitro Cereb Cortex, September 1, 2002; 12(9): 936 - 953. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. F. Casanova, D. P. Buxhoeveden, A. E. Switala, and E. Roy Neuronal Density and Architecture (Gray Level Index) in the Brains of Autistic Patients J Child Neurol, July 1, 2002; 17(7): 515 - 521. [Abstract] [PDF]
|
|
|
|
 |
|
 D. P. Buxhoeveden and M. F. Casanova The minicolumn hypothesis in neuroscience Brain, May 1, 2002; 125(5): 935 - 951. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. E. Maldonado, S. Friedman-Hill, and C. M. Gray Dynamics of Striate Cortical Activity in the Alert Macaque: II. Fast Time Scale Synchronization Cereb Cortex, November 1, 2000; 10(11): 1117 - 1131. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. A. W. Galuske, W. Schlote, H. Bratzke, and W. Singer Interhemispheric Asymmetries of the Modular Structure in Human Temporal Cortex Science, September 15, 2000; 289(5486): 1946 - 1949. [Abstract] [Full Text]
|
|
|
|
 |
|
 E. D. Lumer Effects of Spike Timing on Winner-Take-All Competition in Model Cortical Circuits Neural Comput., January 1, 2000; 12(1): 181 - 194. [Abstract] [Full Text]
|
|
|
|
|
|
G. Gonzalez-Burgos, G. Barrionuevo, and D. A. Lewis Horizontal Synaptic Connections in Monkey Prefrontal Cortex: An In Vitro Electrophysiological Study Cereb Cortex, January 1, 2000; 10(1): 82 - 92. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Roy and K. D. Alloway Synchronization of Local Neural Networks in the Somatosensory Cortex: A Comparison of Stationary and Moving Stimuli J Neurophysiol, March 1, 1999; 81(3): 999 - 1013. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. N. Shadlen and W. T. Newsome The Variable Discharge of Cortical Neurons: Implications for Connectivity, Computation, and Information Coding J. Neurosci., May 15, 1998; 18(10): 3870 - 3896. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Matsumura, D.-f. Chen, T. Sawaguchi, K. Kubota, and E. E. Fetz Synaptic Interactions between Primate Precentral Cortex Neurons Revealed by Spike-Triggered Averaging of Intracellular Membrane Potentials In Vivo J. Neurosci., December 1, 1996; 16(23): 7757 - 7767. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. Horton and D. R. Hocking Intrinsic Variability of Ocular Dominance Column Periodicity in Normal Macaque Monkeys J. Neurosci., November 15, 1996; 16(22): 7228 - 7339. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. S. Ruthazer and M. P. Stryker The Role of Activity in the Development of Long-Range Horizontal Connections in Area 17 of the Ferret J. Neurosci., November 15, 1996; 16(22): 7253 - 7269. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M Stemmler, M Usher, and E Niebur Lateral interactions in primary visual cortex: a model bridging physiology and psychophysics Science, September 29, 1995; 269(5232): 1877 - 1880. [Abstract] [PDF]
|
|
|
|
|
|
R. Douglas, C Koch, M Mahowald, K. Martin, and H. Suarez Recurrent excitation in neocortical circuits Science, August 18, 1995; 269(5226): 981 - 985. [Abstract] [PDF]
|
|
|
|
|
|
G. N. Elston Pyramidal Cells of the Frontal Lobe: All the More Spinous to Think With J. Neurosci., September 15, 2000; 20(18): RC95 - RC95. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. N. Elston and M. G. P. Rosa Pyramidal Cells, Patches, and Cortical Columns: a Comparative Study of Infragranular Neurons in TEO, TE, and the Superior Temporal Polysensory Area of the Macaque Monkey J. Neurosci., December 15, 2000; 20(24): RC117 - RC117. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. N. Elston, R. Benavides-Piccione, and J. DeFelipe The Pyramidal Cell in Cognition: A Comparative Study in Human and Monkey J. Neurosci., September 1, 2001; 21(17): RC163 - RC163. [Abstract] [Full Text] [PDF]
|
|