Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (26)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Mrzljak, L.
Right arrow Articles by Goldman-Rakic, P. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mrzljak, L.
Right arrow Articles by Goldman-Rakic, P. S.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Cerebral Cortex 1993; 3:133-147
© Oxford University Press 1993

research-article

Low-Affinity Nerve Growth Factor Receptor (p75NGFR)- and Choline Acetyltransferase (ChAT)- immunoreactive Axons in the Cerebral Cortex and Hippocampus of Adult Macaque Monkeys and Humans

Ladislav Mrzljak and Patricia S. Goldman-Rakic

Section of Neurobiology, Yale University School of Medicine New Haven, Connecticut 06510

Low-affinity nerve growth factor receptor (p75NGFR) was analyzed in the adult monkey and human cerebral cortex and hippocampus by light and electron microscopic immunohistochemistry using a mouse monoclonal antibody raised against human p75NGFR. In the monkey only, the morphology and laminar and areal distribution of the p75NGFR-immunoreactive fibers were further compared with distribution of the ACh-synthesizing enzyme ChAT. We found that the p75NGFR fiber distribution is remarkably dense throughout the cerebral neocortex and highly similar in homologous cortical areas of monkey and human. In both species, p75NGFR-immunoreactive fibers are contracted in layers I, II, and the superficial portions of layer III in all frontal, parietal, temporal, and occipital areas examined. In the primary visual and somatosensory cortices, dense p75NGFR fiber plexuses are additionally found in layer IV. In the hippocampal formation, this fiber system is most dense in the CA2 and CA3 subfields as well as in the molecular and polymorphic layers of the dentate gyrus. The distribution and characteristics of the p75NGFR-positive fibers in the primates correspond almost exactly to those of the cholinergic fiber system as revealed by ChAT immunohistochemistry in the present study as well as in the literature (Lewis, 1991; Mesulam et al., 1992; Voytko et al., 1992). Electron microscopy revealed that p75NGFR is associated mainly with axonal membranes and portions of the axoplasm in labeled fibers. Although the function of p75NGFR is still a matter of debate, its widespread distribution opens up new questions regarding its physiological role in the large and functionally differentiated cerebral cortex and hippocampus of monkey and human.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Physiol. Rev.Home page
M. A. LYNCH
Long-Term Potentiation and Memory
Physiol Rev, January 1, 2004; 84(1): 87 - 136.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.