Cerebral Cortex 1992; 2:1-15
© Oxford University Press 1992
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Developmental Expression of Estrogen Receptor mRNA in the Rat Cerebral Cortex: A Nonisotopic in situ Hybridization Histochemistry Study
Department of Anatomy and Cell Biology and Center for Reproductive Sciences, Columbia University College of Physicians and Surgeons New York, New York 10032
The distribution of estrogen receptor mRNA expression was studied in the developing rat cerebral cortex by in situ hybridization histochemistry. We used a specific, nonisotopically (digoxigenin) labeled, synthetic oligo deoxyribonucleotide complementary to a 48 base se quence in the region of the estrogen-binding domain of rat uterine estrogen receptor cDNA. During develop ment, estrogen receptor mRNA was observed in all fore brain regions previously reported to bind estrogen, as determined by steroid autoradiography or nuclear bind ing assay. In the developing cerebral cortex, estrogen receptor mRNA was extensively expressed in the ventricular zone, primitive plexiform layer, and immature cortical plate at least as early as embryonic day 16. During the first 3 postnatal weeks, cortical mRNA ex pression was increasingly restricted to the upper third of the cerebral cortex and to the neurons of the cortical subplate (layer VIb/VIl) and decreased to low levels by postnatal day 28. In the cerebral cortex, the spatial distribution of estrogen receptor mRNA expression overlapped that reported for the encoded protein. The extensive distribution of estrogen receptor mRNA throughout the late prenatal and early postnatal cerebral cortex points to an important role for estrogen in the differentiation and maturation of the cerebral cortex.
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