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Cerebral Cortex Advance Access originally published online on April 10, 2009
Cerebral Cortex 2009 19(Supplement 1):i55-i61; doi:10.1093/cercor/bhp042
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© 2009 The Authors
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

This article appears in the following Cerebral Cortex issue: Cortical Development: Neural Stem Cells to Neural Circuits Chania, Greece, May 22-25, 2008 [View the issue table of contents]

Structural Basis for Self-Renewal of Neural Progenitors in Cortical Neurogenesis

Go Shioi1,2, Daijiro Konno1, Atsunori Shitamukai1 and Fumio Matsuzaki1

1 Laboratory for Cell Asymmetry, RIKEN Center for Developmental Biology, Chuo-ku, Kobe 650-0047, Japan

Address correspondence to email: fumio{at}cdb.riken.jp.

In mammalian brain development, neuroepithelial cells act as progenitors that produce self-renewing and differentiating cells. Recent technical advances in live imaging and gene manipulation now enable us to investigate how neural progenitors generate the 2 different types of cells with unprecedented accuracy and resolution, shedding new light on the roles of epithelial structure in cell fate decisions and also on the plasticity of neurogenesis.

Key Words: asymmetric division • neural progenitor • neuroepithelial cell • self-renewal • spindle orientation

2 Current address: Laboratory for Animal Resource and Genetic Engineering, RIKEN Center for Developmental Biology, Chuo-ku, Kobe 650-0047, Japan


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