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Cerebral Cortex Advance Access originally published online on April 22, 2009
Cerebral Cortex 2009 19(Supplement 1):i32-i41; doi:10.1093/cercor/bhp040
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© The Author 2009. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

This article appears in the following Cerebral Cortex issue: Cortical Development: Neural Stem Cells to Neural Circuits Chania, Greece, May 22-25, 2008 [View the issue table of contents]

Neurovascular Congruence during Cerebral Cortical Development

Daniel Stubbs1, Jamin DeProto1, Kai Nie1, Chris Englund2, Imran Mahmud1, Robert Hevner2 and Zoltán Molnár1

1 Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, UK, 2 University of Washington, Department of Neurological Surgery, Seattle Children's Hospital Research Institute, Seattle, WA 98101-1304, USA

Address correspondence to Dr Zoltán Molnár, Department of Physiology, Anatomy and Genetics, Le Gros Clark Building, South Parks Road, University of Oxford, South Parks Road, Oxford, OX1 3QX, UK. Email: zoltan.molnar{at}dpag.ox.ac.uk.

There is evidence for interaction between the developing circulatory and nervous systems. Blood vessels provide a supporting niche in regions of adult neurogenesis. Here we present a systematic analysis of vascular development in the embryonic murine cortex and demonstrate that dividing cells, including Tbr2-positive intermediate progenitor cells, are closer to the vasculature than expected from a random distribution. To examine whether neurites of the newly generated embryonic neurons find blood vessels as an attractive and permissive substrate, we overlayed green fluorescent protein (GFP)-labeled dissociated cortical progenitors on embryonic organotypic cortical slice cultures with labeled vasculature. Our observations of neurites extending toward and along labeled blood vessels support the notion of vascular–neuronal interactions. The altered cortical layering had no obvious effect on the vascular patterns within the cortical plate (CP) in shaking rat Kawasaki (SRK) and the reeler mutant mouse at the ages studied (E19 and P3). It appears that similarly to other neurogenic regions in the adult, the embryonic "vascular niche" might influence neural progenitor cells during telencephalic neurogenesis, neuronal migration, and neurite extension, but the laminar phenotype of cell classes within the CP has limited influence on the developing vasculature.

Key Words: cerebral cortical blood vessels • cerebral cortical neurogenesis • intermediate progenitors • reeler mouse • shaking rat Kawasaki • subventricular zone • Tbr2

Daniel Stubbs and Jamin DeProto contributed equally to this work.


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