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Cerebral Cortex Advance Access originally published online on January 15, 2009
Cerebral Cortex 2009 19(9):2001-2012; doi:10.1093/cercor/bhn232
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© The Author 2009. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

High Consistency of Regional Cortical Thinning in Aging across Multiple Samples

Anders M. Fjell1,2, Lars T. Westlye1, Inge Amlien1, Thomas Espeseth1, Ivar Reinvang1, Naftali Raz3, Ingrid Agartz4,5,6, David H. Salat7, Doug N. Greve7, Bruce Fischl7,8, Anders M Dale9,10,11 and Kristine B. Walhovd1,2

1 Center for the Study of Human Cognition, Department of Psychology, University of Oslo, Olso 0317, Norway, 2 Department of Neuropsychology, Ullevaal University Hospital, Oslo 0317, Norway, 3 Department of Psychology and Institute of Gerontology, Wayne State University, Detroit, MI 48201, USA, 4 Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo 0319, Norway, 5 Department of Psychiatry, University of Oslo, Oslo 0319, Norway, 6 Human Brain Informatics (HUBIN), Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institutet and Hospital, SE-171 76 Stockholm, Sweden, 7 Athinoula A. Martinos Center, Massachusetts General Hospital, Boston, MA 02129, USA, 8 Massachusetts Institute of Technology, Computer Science and Artificial Intelligence Laboratory, Cambridge, MA 02139, USA, 9 Multimodal Imaging Laboratory, 10 Department of Radiology, 11 Department of Neurosciences, University of California, San Diego, CA 92103, USA

Address correspondence to Anders M. Fjell, PhD, Department of Psychology, Pb. 1094 Blindern, 0317 Oslo, Norway. Email: andersmf{at}psykologi.uio.no.

Cross-sectional magnetic resonance imaging (MRI) studies of cortical thickness and volume have shown age effects on large areas, but there are substantial discrepancies across studies regarding the localization and magnitude of effects. These discrepancies hinder understanding of effects of aging on brain morphometry, and limit the potential usefulness of MR in research on healthy and pathological age-related brain changes. The present study was undertaken to overcome this problem by assessing the consistency of age effects on cortical thickness across 6 different samples with a total of 883 participants. A surface-based segmentation procedure (FreeSurfer) was used to calculate cortical thickness continuously across the brain surface. The results showed consistent age effects across samples in the superior, middle, and inferior frontal gyri, superior and middle temporal gyri, precuneus, inferior and superior parietal cortices, fusiform and lingual gyri, and the temporo-parietal junction. The strongest effects were seen in the superior and inferior frontal gyri, as well as superior parts of the temporal lobe. The inferior temporal lobe and anterior cingulate cortices were relatively less affected by age. The results are discussed in relation to leading theories of cognitive aging.

Key Words: aging • cortex • frontal lobes • morphometry • MRI


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A. M. Fjell, L. T. Westlye, I. Amlien, T. Espeseth, I. Reinvang, N. Raz, I. Agartz, D. H. Salat, D. N. Greve, B. Fischl, et al.
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