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Cerebral Cortex Advance Access originally published online on March 17, 2009
Cerebral Cortex 2009 19(8):1705-1707; doi:10.1093/cercor/bhp025
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© The Author 2009. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

New Horizons for the Subplate Zone and Its Pioneering Neurons

Albert E. Ayoub1 and Ivica Kostovic2

1 Department of Neurobiology and Kavli Institute for Neuroscience, Yale University School of Medicine, New Haven, CT 06520, USA, 2 Croatian Institute for Brain Research, School of Medicine, University of Zagreb, 10 000 ZAGREB, Croatia

Address correspondence to email: albert.ayoub{at}yale.edu.

Transitional neuronal layers are a hallmark of the prenatal and neonatal brain yet their contribution to the development of higher functions is not clear. Evidence accumulated over the last 3 decades shows that early connectivity and functional activity start in a transitional layer called the subplate zone (SPZ). The SPZ is host to a heterogenous population of neurons and its evolutionary complexity peaked in the human brain. In this issue of Cerebral Cortex, three reports (Hoerder-Suabedissen et al., 2008; McKellar and Shatz, 2008; Moore et al., 2008) present new data and evidence in three species (mouse, rat, human) as to the function of the SPZ, to the heterogenity of its cellular composition, and to the genetic basis of its development.

Key Words: evolution • gene chip • neocortex • subplate zone • synaptogenesis


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