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Cerebral Cortex Advance Access originally published online on November 2, 2008
Cerebral Cortex 2009 19(7):1557-1566; doi:10.1093/cercor/bhn189
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© The Author 2008. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

The Contributions of Prefrontal Cortex and Executive Control to Deception: Evidence from Activation Likelihood Estimate Meta-analyses

Shawn E. Christ1, David C. Van Essen2, Jason M. Watson3, Lindsay E. Brubaker1 and Kathleen B. McDermott4

1 Department of Psychological Sciences, University of Missouri, Columbia, MO 65203, USA, 2 Department of Anatomy and Neurobiology, Washington University School of Medicine St. Louis, MO 63110 USA, 3 Department of Psychology, University of Utah, Salt Lake City, UT 84112 USA, 4 Department of Psychology, Washington University in St Louis, St. Louis, MO 63130 USA

Address correspondence to Shawn E. Christ, Department of Psychological Sciences, 210 McAlester Hall, University of Missouri, Columbia, MO 65203, USA. Email: christse{at}missouri.edu.

Previous neuroimaging studies have implicated the prefrontal cortex (PFC) and nearby brain regions in deception. This is consistent with the hypothesis that lying involves the executive control system. To date, the nature of the contribution of different aspects of executive control to deception, however, remains unclear. In the present study, we utilized an activation likelihood estimate (ALE) method of meta-analysis to quantitatively identify brain regions that are consistently more active for deceptive responses relative to truthful responses across past studies. We then contrasted the results with additional ALE maps generated for 3 different aspects of executive control: working memory, inhibitory control, and task switching. Deception-related regions in dorsolateral PFC and posterior parietal cortex were selectively associated with working memory. Additional deception regions in ventrolateral PFC, anterior insula, and anterior cingulate cortex were associated with multiple aspects of executive control. In contrast, deception-related regions in bilateral inferior parietal lobule were not associated with any of the 3 executive control constructs. Our findings support the notion that executive control processes, particularly working memory, and their associated neural substrates play an integral role in deception. This work provides a foundation for future research on the neurocognitive basis of deception.

Key Words: anterior cingulate • fMRI • lie detection • lying • neuroimaging • prefrontal cortex


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