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Cerebral Cortex Advance Access originally published online on September 18, 2008
Cerebral Cortex 2009 19(4):951-962; doi:10.1093/cercor/bhn130
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© The Author 2008. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

L2/3 Interneuron Groups Defined by Multiparameter Analysis of Axonal Projection, Dendritic Geometry, and Electrical Excitability

Moritz Helmstaedter1, Bert Sakmann1 and Dirk Feldmeyer2,3

1 Department of Cell Physiology, Max-Planck Institute for Medical Research, Jahnstrasse 29, D-69120 Heidelberg, Germany, 2 Forschungszentrum Jülich, Institut für Neurowissenschaften und Biophysik, INB-3 Medizin, Leo-Brandt-Strasse, D-52425 Jülich, Germany, 3 Department of Psychiatry and Psychotherapy, University Hospital Aachen, RWTH Aachen University, Pauwelsstrasse 30, D-52074 Aachen

Address correspondence to Moritz Helmstaedter, Department of Cell Physiology, Max-Planck Institute for Medical Research, Jahnstrasse 29, D-69120 Heidelberg, Germany. Email: moritz.helmstaedter{at}mpimf-heidelberg.mpg.de.

For a detailed description of the circuitry of cortical columns at the level of single neurons, it is essential to define the identities of the cell types that constitute these columns. For interneurons (INs), we described 4 "types of axonal projection patterns" in layer 2/3 (L2/3) with reference to the outlines of a cortical column (Helmstaedter et al. 2008a). In addition we quantified the dendritic geometry and electrical excitability of 3 types of the L2/3 INs: "local," "lateral," and "translaminar" inhibitors (Helmstaedter et al. 2008b). Here, we used an iterated cluster analysis (iCA) that combines axonal projection patterns with dendritic geometry and electrical excitability parameters to identify "groups" of INs, from a sample of 39 cells. The iCA defined 9 groups of INs. We propose a hierarchical scheme for identifying L2/3 INs. First, L2/3 INs can be classified as 4 types of axonal projections. Second, L2/3 INs can be subclassified as 9 groups with a high within-group similarity of dendritic, axonal, and electrical parameters. This scheme of identifying L2/3 INs may help to quantitatively describe inhibitory effects on sensory stimulus representations in L2/3 of cortical columns.

Key Words: axons • barrel cortex • cluster analysis • dendrites • electrical excitability • GABAergic interneuron • lateral inhibition • layer 2/3


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