Skip Navigation


Cerebral Cortex Advance Access originally published online on July 31, 2008
Cerebral Cortex 2009 19(4):777-785; doi:10.1093/cercor/bhn124
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
19/4/777    most recent
bhn124v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Makris, N.
Right arrow Articles by Pandya, D. N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Makris, N.
Right arrow Articles by Pandya, D. N.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2008. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Delineation of the Middle Longitudinal Fascicle in Humans: A Quantitative, In Vivo, DT-MRI Study

Nikos Makris1,2, George M. Papadimitriou1, Jonathan R. Kaiser1, Scott Sorg1, David N. Kennedy1 and Deepak N. Pandya2

1 Harvard Medical School Departments of Psychiatry, Neurology and Radiology Services, Center for Morphometric Analysis, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA 02129, USA, 2 Boston University School of Medicine, Department of Anatomy and Neurobiology, Boston, MA 02215, USA

Address correspondence to Nikos Makris, MD, PhD, Massachusetts General Hospital, Center for Morphometric Analysis, Building 149, 13th Street, Charlestown, MA 02129, USA. Email: nikos{at}cma.mgh.harvard.edu.

Experimental and imaging studies in monkeys have outlined various long association fiber bundles within the temporoparietal region. In the present study the trajectory of the middle longitudinal fascicle (MdLF) has been delineated in 4 human subjects using diffusion tensor magnetic resonance imaging segmentation and tractography. The MdLF seems to extend from the inferior parietal lobule (IPL), specifically the angular gyrus, to the temporal pole remaining within the white matter of the superior temporal gyrus (STG). Comparison of the superior longitudinal fascicle II-arcuate fascicle (SLF II-AF) with the MdLF in the same subjects revealed that MdLF is located in a medial and caudal position relative to SLF II-AF and that it extends more rostrally. Given the location of MdLF between the IPL (angular gyrus) and the STG, it is suggested that MdLF could have a role in language and attention functions.

Key Words: DT-MRI • middle longitudinal fascicle • segmentation • tractography

Human Research Statement: The experiments undertaken in this paper were performed with the understanding and written informed consent of each subject.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Proc. Natl. Acad. Sci. USAHome page
D. Saur, B. W. Kreher, S. Schnell, D. Kummerer, P. Kellmeyer, M.-S. Vry, R. Umarova, M. Musso, V. Glauche, S. Abel, et al.
Ventral and dorsal pathways for language
PNAS, November 18, 2008; 105(46): 18035 - 18040.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
S. Frey, J. S. W. Campbell, G. B. Pike, and M. Petrides
Dissociating the Human Language Pathways with High Angular Resolution Diffusion Fiber Tractography
J. Neurosci., November 5, 2008; 28(45): 11435 - 11444.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.