Skip Navigation


Cerebral Cortex Advance Access originally published online on April 9, 2008
Cerebral Cortex 2009 19(1):72-78; doi:10.1093/cercor/bhn059
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
19/1/72    most recent
bhn059v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Greicius, M. D.
Right arrow Articles by Dougherty, R. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Greicius, M. D.
Right arrow Articles by Dougherty, R. F.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2008. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Resting-State Functional Connectivity Reflects Structural Connectivity in the Default Mode Network

Michael D. Greicius1,3, Kaustubh Supekar4, Vinod Menon2,3 and Robert F. Dougherty5

1 Department of Neurology, Stanford University School of Medicine, Stanford, CA 94304, USA, 2 Department of Psychiatry, Stanford University School of Medicine, Stanford, CA 94304, USA, 3 Program in Neuroscience, Stanford University, Stanford, CA 94304, USA, 4 Department of Biomedical Informatics, Stanford University School of Medicine, Stanford, CA 94304, USA, 5 Department of Psychology, Stanford University, Stanford, CA 94304, USA

Address correspondence to Michael D. Grecius, MD 300 Pasteur Drive, Room A343 Stanford, CA 94305-5235. Email: greicius{at}stanford.edu.

Resting-state functional connectivity magnetic resonance imaging (fcMRI) studies constitute a growing proportion of functional brain imaging publications. This approach detects temporal correlations in spontaneous blood oxygen level–dependent (BOLD) signal oscillations while subjects rest quietly in the scanner. Although distinct resting-state networks related to vision, language, executive processing, and other sensory and cognitive domains have been identified, considerable skepticism remains as to whether resting-state functional connectivity maps reflect neural connectivity or simply track BOLD signal correlations driven by nonneural artifact. Here we combine diffusion tensor imaging (DTI) tractography with resting-state fcMRI to test the hypothesis that resting-state functional connectivity reflects structural connectivity. These 2 modalities were used to investigate connectivity within the default mode network, a set of brain regions—including medial prefrontal cortex (MPFC), medial temporal lobes (MTLs), and posterior cingulate cortex (PCC)/retropslenial cortex (RSC)—implicated in episodic memory processing. Using seed regions from the functional connectivity maps, the DTI analysis revealed robust structural connections between the MTLs and the retrosplenial cortex whereas tracts from the MPFC contacted the PCC (just rostral to the RSC). The results demonstrate that resting-state functional connectivity reflects structural connectivity and that combining modalities can enrich our understanding of these canonical brain networks.

Key Words: Alzheimer's disease • hippocampus • memory • posterior cingulate • retrosplenial • white matter


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Neurosci.Home page
C. Habas, N. Kamdar, D. Nguyen, K. Prater, C. F. Beckmann, V. Menon, and M. D. Greicius
Distinct Cerebellar Contributions to Intrinsic Connectivity Networks
J. Neurosci., July 1, 2009; 29(26): 8586 - 8594.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. P. van den Heuvel, C. J. Stam, R. S. Kahn, and H. E. Hulshoff Pol
Efficiency of Functional Brain Networks and Intellectual Performance
J. Neurosci., June 10, 2009; 29(23): 7619 - 7624.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
R. L. Buckner, J. Sepulcre, T. Talukdar, F. M. Krienen, H. Liu, T. Hedden, J. R. Andrews-Hanna, R. A. Sperling, and K. A. Johnson
Cortical Hubs Revealed by Intrinsic Functional Connectivity: Mapping, Assessment of Stability, and Relation to Alzheimer's Disease
J. Neurosci., February 11, 2009; 29(6): 1860 - 1873.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
C. J. Honey, O. Sporns, L. Cammoun, X. Gigandet, J. P. Thiran, R. Meuli, and P. Hagmann
Predicting human resting-state functional connectivity from structural connectivity
PNAS, February 10, 2009; 106(6): 2035 - 2040.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
D. Zhang, A. Z. Snyder, M. D. Fox, M. W. Sansbury, J. S. Shimony, and M. E. Raichle
Intrinsic Functional Relations Between Human Cerebral Cortex and Thalamus
J Neurophysiol, October 1, 2008; 100(4): 1740 - 1748.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.