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Cerebral Cortex Advance Access originally published online on May 22, 2008
Cerebral Cortex 2009 19(1):241-248; doi:10.1093/cercor/bhn077
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© The Author 2008. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Vesicular Glutamate and GABA Transporters Sort to Distinct Sets of Vesicles in a Population of Presynaptic Terminals

Jean-Luc Boulland1,2, Monica Jenstad1,2, Amber J. Boekel3, Floris G. Wouterlood3, Robert H. Edwards4, Jon Storm-Mathisen2 and Farrukh A. Chaudhry1,2

1 The Biotechnology Centre of Oslo, 2 The Centre for Molecular Biology & Neuroscience, University of Oslo, Norway, 3 Department of Anatomy, Vrije Universiteit Medical Centre, Amsterdam, The Netherlands, 4 Departments of Neurology and Physiology, UCSF School of Medicine, San Francisco, CA, USA

Address correspondence to Farrukh A. Chaudhry, MD, PhD, University of Oslo, The Biotechnology Centre of Oslo, P.O. Box 1125 Blindern, N-0317 Oslo, Norway. Email: f.a.chaudhry{at}biotek.uio.no.

Vesicular glutamate transporters (VGLUTs) 1 and 2 are expressed by neurons generally accepted to release glutamate as a neurotransmitter, whereas VGLUT3 appears in populations usually associated with a different classical transmitter. We now demonstrate VGLUT2 as well as the vesicular GABA transporter (VGAT) in a subset of presynaptic terminals in the dentate gyrus of the rat hippocampal formation. The terminals are distributed in a characteristic band overlapping with the outer part of the granule cell layer and the inner zone of the molecular layer. Within the terminals, which make asymmetric as well as symmetric synapses onto the somatodendritic compartment of the dentate granule cells, the 2 transporters localize to distinct populations of synaptic vesicles. Moreover, the axons forming these terminals originate in the supramammillary nucleus (SuM). Our data reconcile previous apparently conflicting reports on the physiology of the dentate afferents from SuM and demonstrate that both glutamate and GABA may be released from a single nerve terminal.

Key Words: corelease • interneuron • supramammillary nucleus • theta activity • VGAT • VGLUT2


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