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Cerebral Cortex Advance Access originally published online on April 24, 2008
Cerebral Cortex 2009 19(1):134-145; doi:10.1093/cercor/bhn063
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© The Author 2008. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Sensory MEG Responses Predict Successful and Failed Inhibition in a Stop-Signal Task

C. N. Boehler1, T. F. Münte2, R. M. Krebs3, H. -J. Heinze1,3, M. A. Schoenfeld1,3,4 and J. -M. Hopf1,3

1 Leibniz-Institute for Neurobiology, 39118 Magdeburg, Germany, 2 Department of Neuropsychology, Otto-von-Guericke-University, 39106 Magdeburg, Germany, 3 Department of Neurology II, Otto-von-Guericke-University, 39120 Magdeburg, Germany, 4 Kliniken Schmieder, 78476 Allensbach, Germany

Address corresponding to C. Nicolas Boehler, Leibniz Institute for Neurobiology, Brenneckstr. 6, 39118 Magdeburg, Germany. Email: boehler{at}neuro2.med.uni-magdeburg.de.

In the present study magnetoencephalographic recordings were performed to investigate the neural mechanisms underlying the stopping of manual responses. Subjects performed in a Stop-signal task in which Go-stimuli (S1), requiring a rapid motor response, were sometimes rapidly followed by a Stop-stimulus (S2) indicating to withhold the already initiated response to S1. Success of stopping strongly depended on the early perceptual processing of S1 and S2 reflected by the magnetic N1 component. Enhanced processing of S1 facilitated the execution of the movement, whereas enhanced processing of S2 favored its inhibition. This suggests that the processing resources for the subsequent stimuli are limited and need to be shared. This sharing of resources appeared to arise from adjustments made on a trial-by-trial basis, in that systematic reaction time prolongations on Go-trials following Stop-trials versus following Go-trials were accompanied by attenuated sensory processing to the Go-stimulus similar to that seen in successful versus unsuccessful stopping in Stop-trials.

Key Words: executive function • inhibition • MEG • posterior cingulate gyrus • stop-paradigm • visual attention


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