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Cerebral Cortex Advance Access originally published online on November 17, 2007
Cerebral Cortex 2008 18(7):1653-1663; doi:10.1093/cercor/bhm193
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© The Author 2007. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Involvement of the mGluR1 Receptor in Hippocampal Synaptic Plasticity and Associative Learning in Behaving Mice

Cristina Gil-Sanz1, José M. Delgado-García2, Alfonso Fairén1 and Agnès Gruart2

1 Instituto de Neurociencias de Alicante, CSIC and Universidad Miguel Hernández, E-03550 San Juan de Alicante, Spain, 2 División de Neurociencias, Universidad Pablo de Olavide, Ctra. de Utrera, Km. 1, E-41013 Sevilla, Spain

Address correspondence to Dr Agnès Gruart. Email: agrumas{at}upo.es.

Metabotropic glutamate receptor 1 (mGluR1) has been related to processes underlying learning in hippocampal circuits, but demonstrating its involvement in synaptic plasticity when measured directly on the relevant circuit of a learning animal has proved to be technically difficult. We have recorded the functional changes taking place at the hippocampal CA3–CA1 synapse during the acquisition of an associative task in conscious mice carrying a targeted disruption of the mGluR1 gene. Animals were classically conditioned to evoke eyelid responses, using a trace (conditioned stimulus [CS], tone; unconditioned stimulus [US], electric shock) paradigm. Acquisition of this task was impaired in mutant mGluR1+/– mice and abolished in mGluR1–/– mice. A single pulse presented to Schaffer collaterals during the CS–US interval evoked a monosynaptic field excitatory postsynaptic potential at ipsilateral CA1 pyramidal cells, whose slope was linearly related to learning evolution in controls but not in mGluR1 mutants. Long-term potentiation evoked by train stimulation of Schaffer collaterals was also impaired in both mGluR1+/– and mGluR1–/– animals. Administration of the selective mGluR1 antagonist (3aS,6aS)-6a-naphthalen-2-ylmethyl-5-methyliden-hexahydro-cyclopental [c]furan-1-on to wild-type animals mimicked the functional changes associated to mGluR1 insufficiency in mutants. Thus, mGluR1 is required for activity-dependent synaptic plasticity and associative learning in behaving mice.

Key Words: BAY36-7620 • classical conditioning • hippocampus • long-term potentiation • mGluR1 receptor • synaptic plasticity


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[Abstract] [Full Text] [PDF]


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