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Cerebral Cortex Advance Access originally published online on July 21, 2007
Cerebral Cortex 2008 18(4):846-867; doi:10.1093/cercor/bhm116
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© The Author 2007. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Observer-Independent Cytoarchitectonic Mapping of the Human Superior Parietal Cortex

Filip Scheperjans1,2, Klaudia Hermann1,2, Simon B. Eickhoff1, Katrin Amunts1,3, Axel Schleicher2 and Karl Zilles1,2

1 Institute of Medicine, Research Center Jülich and Brain Imaging Center West, D-52425 Jülich, Germany, 2 C. and O. Vogt Institute for Brain Research, University of Düsseldorf, D-40001 Düsseldorf, Germany, 3 Department of Psychiatry and Psychotherapy, Aachen University Hospital, D-52074 Aachen, Germany

Address correspondence to email: filip{at}gmx.net.

The human superior parietal cortex (SPC; Brodmann areas [BA] 5 and 7) comprises the superior parietal lobule and medial wall of the intraparietal sulcus (mIPS) laterally and the posterior paracentral lobule and precuneus medially. Receptor autoradiographic and functional studies indicate more complex segregations in the SPC than suggested by Brodmann (1909). Differences to other historical maps may be due to anatomical variability between brains and different definition criteria for areas. To provide a reliable anatomical reference of the SPC, we performed an observer-independent cytoarchitectonic mapping of this region in 10 human postmortem brains. Cytoarchitecture was analyzed in cell-body–stained brain sections using gray-level index profiles. Multivariate statistical analysis of profile shape allowed the exact localization of cytoarchitectonic borders and quantification of interareal differences. We identified 3 areas in BA 5 (5L, 5M, and 5Ci), 4 in BA 7 (7PC, 7A, 7P, and 7M), and 1 in the anterior mIPS (hIP3). Locations of their borders relative to macroanatomical landmarks varied considerably between brains and hemispheres. Cytoarchitectonic profiles of areas 5Ci and hIP3 differed most from those of the remaining areas, and differences between subareas were stronger in BA 5 than in BA 7. These areas are possible structural correlates of functional segregations within the SPC.

Key Words: area 5 • area 7 • brain mapping • intraparietal sulcus (IPS) • precuneus • superior parietal lobule (SPL)


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