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Cerebral Cortex Advance Access originally published online on October 5, 2006
Cerebral Cortex 2007 17(8):1788-1799; doi:10.1093/cercor/bhl089
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© The Author 2006. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Functional Connectivity of Frontal Cortex in Healthy and ADHD Children Reflected in EEG Coherence

Michael Murias1, James M. Swanson2,3 and Ramesh Srinivasan4

1 Autism Center, Center on Human Development and Disability, University of Washington, Seattle, WA, USA, 2 Child Development Center, University of California, Irvine, Irvine, CA, USA, 3 The Sacker Institute of Cornell University, NY, USA, 4 Department of Cognitive Sciences, University of California, Irvine, Irvine, CA, USA

Address correspondence to email: mmurias{at}u.washington.edu.

Abnormal functional brain connectivity is a candidate factor in developmental brain disorders associated with cognitive dysfunction. We analyzed a substantial (10 min per subject) record of dense array electroencephalography with spectral power and coherence methods in attention-deficit hyperactivity disorder (ADHD) (n = 42) and control (n = 21) 10- to 13-year-old children. We found topographically distinct narrow band coherence differences between subject groups: ADHD subjects showed elevated coherence in the lower alpha (8 Hz) band and reduced coherence in the upper alpha (10–11 Hz) band. The 8-Hz ADHD elevation and a 2- to 6-Hz control group coherence elevation were independent of stimulus presentation. In response to visual stimulation, the ADHD group exhibited reduced evoked potential power and elevated frontal coherence. Only the upper alpha band control group coherence elevation discriminated according to ADHD group medication status. The findings suggest a static state of deficient connectivity in ADHD and a stimulus-induced state of overconnectivity within and between frontal hemispheres.

Key Words: alpha rhythm • attention deficit/hyperactivity disorder • induced rhythms • pediatric EEG • synchrony


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