Cerebral Cortex Advance Access originally published online on May 12, 2006
Cerebral Cortex 2007 17(4):766-777; doi:10.1093/cercor/bhk030
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Extrinsic and Intrinsic Systems in the Posterior Cortex of the Human Brain Revealed during Natural Sensory Stimulation
1 Department of Psychology, Hebrew University of Jerusalem, Jerusalem, Israel, 2 Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel, 3 Department of Statistics and Operations Research, Tel-Aviv University, Tel-Aviv, Israel, 4 Centre for Neural Science, New York University, New York, USA
Address correspondence to Professor Rafael Malach, Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel. Email: rafi.malach{at}weizmann.ac.il.
When exposing subjects to a continuous segment of an audiovisual movie, a large expanse of human cortex, especially in the posterior half of the cerebral cortex, shows stimulus-driven activity. However, embedded within this widespread activity, there are cortical regions whose activity is dissociated from the external stimulation. These regions are intercorrelated among themselves, forming a functional network, which largely overlaps with cortical areas previously shown to be deactivated by task-oriented paradigms. Moreover, the network of areas whose neuronal dynamics are associated with external inputs and the network of areas that appears to be intrinsically driven complement each other, providing coverage of most of the posterior cortex. Thus, we propose that naturalistic stimuli reveal a fundamental neuroanatomical partition of the human posterior cortex into 2 global networks: an "extrinsic" system, comprising areas associated with the processing of external inputs, and an "intrinsic" system, largely overlapping with the task-negative, default-mode network, comprising areas associated with—as yet not fully understood—intrinsically oriented functions.
Key Words: default mode • fMRI • global network • intrinsic • natural viewing
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