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Cerebral Cortex Advance Access originally published online on April 7, 2006
Cerebral Cortex 2007 17(3):542-551; doi:10.1093/cercor/bhj179
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© The Author 2006. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org
The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions@oupjournals.org.

Word Reading and Posterior Temporal Dysfunction in Amnestic Mild Cognitive Impairment

Mathieu Vandenbulcke1,2, Ronald Peeters3, Patrick Dupont4, Paul Van Hecke3 and Rik Vandenberghe1,5

1 Cognitive Neurology Laboratory, Experimental Neurology Division, Katholieke Universiteit Leuven, Belgium, 2 Psychiatry Department, 3 Radiology Department, 4 Nuclear Medicine Department, 5 Neurology Department, University Hospital Gasthuisberg, Leuven, Belgium

Address correspondence to Rik Vandenberghe, MD, PhD, Neurology Department, University Hospital Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium. Email: rik.vandenberghe{at}uz.kuleuven.ac.be.

Patient studies that combine functional magnetic resonance imaging with chronometric analysis of language dysfunction may reveal the critical contribution of brain areas to language processes as well as shed light on disease pathogenesis. In amnestic mild cognitive impairment (MCI), a prodromal stage of Alzheimer's disease, we examined whether the brain system for associative-semantic judgments with words or with pictures is affected and how this relates to off-line chronometric analysis of word reading and picture naming. A consecutive memory clinic–based series of 13 amnestic MCI patients as well as 13 matched controls participated. One area, the lower bank of the posterior third of the left superior temporal sulcus (STS), showed a significant group-by-task interaction: In controls, it was activated during the associative-semantic condition with words compared with the visuoperceptual control condition but not when the same tasks were compared with pictures as input. In MCI, this word-specific activation was significantly reduced. Response amplitude correlated (r = 0.90) with the steepness of the slope of the time-accuracy curve for word reading. Our data provide converging evidence for a critical contribution of the lower bank of the left posterior STS to mapping word form onto word meaning (lexical-semantic retrieval).

Key Words: alzheimer • fMRI • language • lexical • semantic

Funding to pay the Open Access publication charges for this article was provided by KU Leuven Research Fund OT/04/41.


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