Skip Navigation


Cerebral Cortex Advance Access originally published online on March 26, 2007
Cerebral Cortex 2007 17(12):2980-2987; doi:10.1093/cercor/bhm023
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrowOA All Versions of this Article:
17/12/2980    most recent
bhm023v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (1)
Google Scholar
Right arrow Articles by Loubinoux, I.
Right arrow Articles by Chollet, F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Loubinoux, I.
Right arrow Articles by Chollet, F.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 2007 The Authors
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Prognostic Value of fMRI in Recovery of Hand Function in Subcortical Stroke Patients

Isabelle Loubinoux1,2, S. Dechaumont-Palacin3, E. Castel-Lacanal4, X. De Boissezon4, Philippe Marque4, Jérémie Pariente1,2,3, Jean-François Albucher3, Isabelle Berry5 and François Chollet1,2,3

1 INSERM U455, Pavillon Riser, Purpan Hospital, 31059 Toulouse, France, 2 Université Paul-Sabatier, Toulouse, F-31062 France, 3 Department of Neurology, Pavillon Riser, Purpan Hospital, 31059 Toulouse, France, 4 Department of Rehabilitation and Physical Medicine, Rangueil Hospital, Toulouse, France, 5 Department of Neuroradiology, Purpan Hospital, 31059 Toulouse, France

Address correspondence to email: Isabelle.Loubinoux{at}toulouse.inserm.fr.

The first objective of the study was to determine whether functional magnetic resonance imaging (fMRI) signal was correlated with motor performance at different stages of poststroke recovery. The second objective was to assess the existence of prognostic factors for recovery in early functional MR images. Eight right-handed patients with pure motor deficit secondary to a first lacunar infarct localized on the pyramidal tract were included. This study concerned moderately impaired patients and recovery of handgrip strength and finger-tapping speed. The fMRI task was a calibrated flexion–extension movement. Ten healthy subjects served as a control group. The intensity of the activation in the "classical" motor network (ipsilesional S1M1, ipsilesional ventral premotor cortex [BA 6], contralesional cerebellum) 20 days after stroke was indicative of the performance (positive correlation). The cluster in M1 was posterior and circumscribed to BA 4p. No area was associated with bad performance (negative correlation). No correlation was found 4 and 12 months after stroke. Prognosis factors were evidenced. The higher early the activation in the ipsilesional M1 (BA 4p), S1, and insula, the better the recovery 1 year after stroke. Although the lesions partly deefferented the primary motor cortex, patients who activated the posterior primary motor cortex early had a better recovery of hand function. This suggests that there is benefit in increasing ipsilesional M1 activity shortly after stroke as a rehabilitative approach in mildly impaired patients.

Key Words: fMRI • longitudinal study • motor recovery • prognosis • stroke


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 StrokeHome page
A. G. Sorensen and W.-D. Heiss
Advances in Imaging 2007
Stroke, February 1, 2008; 39(2): 276 - 278.
[Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.