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Cerebral Cortex Advance Access originally published online on March 29, 2007
Cerebral Cortex 2007 17(12):2949-2960; doi:10.1093/cercor/bhm021
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© The Author 2007. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Laminar Specificity of Intrinsic Connections in Broca's Area

Eric Tardif1,2, Alphonse Probst3 and Stephanie Clarke1

1 Service de Neuropsychologie et de Neuroréhabilitation, CHUV, Université de Lausanne, CH-1011 Lausanne, Switzerland, 2 Département de Biologie Cellulaire et de Morphologie, Université de Lausanne, CH-1011 Lausanne, Switzerland, 3 Institut für Pathologie, Universität CH-4002 Basel, Switzerland

Address correspondence to Prof S. Clarke, Service de Neuropsychologie et de Neuroréhabilitation, CHUV, Université de Lausanne, 1011 Lausanne, Switzerland. Email: stephanie.clarke{at}chuv.ch.

Broca's area and its right hemisphere homologue comprise 2 cytoarchitectonic subdivisions, FD{Gamma} and FCBm of von Economo C and Koskinas GN (1925, Die Cytoarchitektonik der Hirnrinde des erwachsenen Menschen. Vienna/Berlin [Germany]: Springer). We report here on intrinsic connections within these areas, as revealed with biotinylated dextran amine and 1,1'-dioctadecyl-3,3,3',3'-tetramethylindocarbocyanine perchlorate tracing in postmortem human brains. Injections limited to supragranular layers revealed a complex intrinsic network of horizontal connections within layers II and III spreading over several millimeters and to a lesser extent within layers IV, V, and VI. Ninety percent of the retrogradely labeled neurons (n = 734) were in supragranular layers, 4% in layer IV, and 6% in infragranular layers; most were pyramids and tended to be grouped into clusters of approximately 500 µm in diameter. Injections involving layer IV revealed extended horizontal connections within layers I–IV (up to 3.7 mm) and to a lesser extent in layers V and VI. Injections limited to the infragranular layers revealed horizontal connections mainly limited to these layers. Thus, intrinsic connections within Broca's area display a strong laminar specificity. This pattern is very similar in areas FD{Gamma} and FCBm and in the 2 hemispheres.

Key Words: BDA • cerebral cortex • DiI • human • inferior frontal gyrus • tracing


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