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Cerebral Cortex Advance Access originally published online on March 29, 2007
Cerebral Cortex 2007 17(12):2866-2877; doi:10.1093/cercor/bhm019
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© 2007 The Authors
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Cortical Response Field Dynamics in Cat Visual Cortex

Dahlia Sharon1, Dirk Jancke2, Frédéric Chavane3, Shmuel Na'aman and Amiram Grinvald

Neurobiology Department, Weizmann Institute of Science, Rehovot 76100, Israel, 1 Current address: Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA 02129, USA, 2 Current address: Department of Cognitive Neurobiology, Ruhr-University Bochum, D-44780 Bochum, Germany, 3 Current address: INCM, UMR6193, CNRS—Aix-Marseille Université, 31 Chemin Joseph Aiguier, 13402 Marseille Cedex 20, France

Address correspondence to email: dahlia{at}nmr.mgh.harvard.edu.

Little is known about the "inverse" of the receptive field—the region of cortical space whose spatiotemporal pattern of electrical activity is influenced by a given sensory stimulus. We refer to this activated area as the cortical response field, the properties of which remain unexplored. Here, the dynamics of cortical response fields evoked in visual cortex by small, local drifting-oriented gratings were explored using voltage-sensitive dyes. We found that the cortical response field was often characterized by a plateau of activity, beyond the rim of which activity diminished quickly. Plateau rim location was largely independent of stimulus orientation. However, approximately 20 ms following plateau onset, 1–3 peaks emerged on it and were amplified for 25 ms. Spiking was limited to the peak zones, whose location strongly depended on stimulus orientation. Thus, alongside selective amplification of a spatially restricted suprathreshold response, wider activation to just below threshold encompasses all orientation domains within a well-defined retinotopic vicinity of the current stimulus, priming the cortex for processing of subsequent stimuli.

Key Words: area 18 • local oriented grating • optical imaging • orientation map • voltage-sensitive dye imaging


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