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Cerebral Cortex Advance Access originally published online on January 30, 2007
Cerebral Cortex 2007 17(11):2625-2633; doi:10.1093/cercor/bhl170
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© The Author 2007. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Right TPJ Deactivation during Visual Search: Functional Significance and Support for a Filter Hypothesis

Gordon L. Shulman1, Serguei V. Astafiev2, Mark P. McAvoy2, Giovanni d'Avossa1 and Maurizio Corbetta1,2,3

1 Department of Neurology, 2 Department of Radiology, 3 Department of Anatomy and Neurobiology, Washington University, St Louis, MO 63110, USA

Address correspondence to Gordon L. Shulman, Department of Neurology, Box 8111, 4525 Scott Avenue, Room no. 2109, St Louis, MO 63110, USA. Email: gordon{at}npg.wustl.edu.

Behavioral performance depends on attending to important objects in the environment rather than irrelevant objects. Regions in the right temporal–parietal junction (TPJ) are thought to be involved in redirecting attention to new objects that are behaviorally relevant. When subjects monitor a stream of distracter objects for a target, TPJ deactivates until the target is detected. We have proposed that the deactivation reflects the filtering of irrelevant inputs from TPJ, preventing unimportant objects from being attended. This hypothesis predicts that the mean deactivation to distracters should be larger when the subsequent target is detected than missed, reflecting more efficient filtering. An analysis of the blood oxygenation level–dependent (BOLD) task-evoked signals from 20 subjects during 2 monitoring tasks confirmed this prediction for regions in right supramarginal gyrus (SMG). Because the deactivation preceded the target, this mean BOLD-detection relationship did not reflect feedback from target detection or postdetection processes. The SMG regions showing this relationship overlapped or neighbored some regions associated with a "default" mode of brain function, suggesting the functional significance of deactivations in some default regions during task performance.

Key Words: attention • default system • FMRI • TPJ • vision


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