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Cerebral Cortex Advance Access originally published online on January 4, 2007
Cerebral Cortex 2007 17(11):2544-2552; doi:10.1093/cercor/bhl160
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© 2007 The Authors
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Working Memory–Specific Activity in Auditory Cortex: Potential Correlates of Sequential Processing and Maintenance

André Brechmann1, Birgit Gaschler-Markefski1, Mandy Sohr1, Koichi Yoneda1,2, Thomas Kaulisch1 and Henning Scheich1

1 Non-Invasive Brain Imaging, Leibniz Institute for Neurobiology, D-39118 Magdeburg, Germany, 2 Faculty of Medicine, Kagoshima University, Sakuragaoka 4-3-1-2654, Kagoshima City 891-0175, Japan

Address correspondence to André Brechmann, Leibniz Institute for Neurobiology, Brenneckestrasse 6, 39118 Magdeburg, Germany. Email: brechman{at}ifn-magdeburg.de.

Working memory (WM) tasks involve several interrelated processes during which past information must be transiently maintained, recalled, and compared with test items according to previously instructed rules. It is not clear whether the rule-specific comparisons of perceptual with memorized items are only performed in previously identified frontal and parietal WM areas or whether these areas orchestrate such comparisons by feedback to sensory cortex. We tested the latter hypothesis by focusing on auditory cortex (AC) areas with low-noise functional magnetic resonance imaging in a 2-back WM task involving frequency-modulated (FM) tones. The control condition was a 0-back task on the same stimuli. Analysis of the group data identified an area on right planum temporale equally activated by both tasks and an area on the left planum temporale specifically involved in the 2-back task. A region of interest analysis in each individual revealed that activation on the left planum temporale in the 2-back task positively correlated with the task performance of the subjects. This strongly suggests a prominent role of the AC in 2-back WM tasks. In conjunction with previous findings on FM processing, the left lateralized effect presumably reflects the complex sequential processing demand of the 2-back matching to sample task.

Key Words: fMRI • hemispheric specialization • n-back • planum temporale • task performance

Funding to pay the Open Access publication charges for this article was provided by the BMBF Center for Advanced Imaging, DFG, Graduiertenkolleg 253, and SFB 426.


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