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Cerebral Cortex Advance Access originally published online on January 4, 2007
Cerebral Cortex 2007 17(11):2516-2525; doi:10.1093/cercor/bhl157
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© The Author 2007. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Plastic Phase-Locking and Magnetic Mismatch Response to Auditory Deviants in Temporal Lobe Epilepsy

Yung-Yang Lin1,2,3,4,5,6,7, Fu-Jung Hsiao1,6, Yang-Hsin Shih5,7, Chun-Hing Yiu2,7, Der-Jen Yen2,7, Sheong-Yeong Kwan2,7, Tai-Tong Wong5,7, Zin-An Wu2,7 and Low-Tone Ho1,6

1 Institute of Physiology, 2 Department of Neurology, 3 Institute of Clinical Medicine, 4 Institute of Brain Science, 5 School of Medicine, National Yang-Ming University, Taipei, Taiwan, 6 Department of Medical Research and Education, 7 Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan

Address correspondence to Dr Yung-Yang Lin, Institute of Physiology, National Yang-Ming University, No. 155, Sec. 2, Linong St., Beitou District, Taipei City 112, Taiwan. Email: yylin{at}vghtpe.gov.tw.

The magnetic equivalent (MMNm) of mismatch negativity may reflect auditory discrimination and sensory memory. To study whether temporal lobe epilepsy (TLE) affects automatic central auditory-change processing, we recorded magnetoencephalographic (MEG) responses to standard and duration-deviant sounds in 12 TLE patients and 12 age-matched controls, and repeated MEG measurement in 8 patients 6–30 months following epilepsy surgery and in 6 controls 3–8 months after their first measurement. We compared the MMNm between patients and controls, and also evaluated intertrial phase coherences as indexed by phase-locking factors (PLF) using wavelet-based analyses. We observed longer MMNm latencies for patients than for controls. Dipole modeling and minimum-current estimates together showed bi-frontotemporal sources for MMNm. The phase locking across trials was dominant at the 4- to 14-Hz band, and the main difference in PLF between deviant- and standard-evoked responses occurred in the time frame of 150–250 ms after stimulus onset. Notably, in the 5 patients who became seizure free after removal of right temporal epileptic focus, the phase-locking phenomena resulting from deviant stimuli were enhanced, and even more distributed in the frontotemporal regions. We conclude that mesial TLE might affect auditory-change detection, and a successful surgery causes a possible plastic change in phase locking of deviant-evoked signals.

Key Words: auditory MMNm • magnetoencephalography • neural plasticity • phase-locking • temporal lobe epilepsy


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