Cerebral Cortex Advance Access originally published online on December 27, 2006
Cerebral Cortex 2007 17(10):2375-2386; doi:10.1093/cercor/bhl146
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Involvement of the Myelin-Associated Inhibitor Nogo-A in Early Cortical Development and Neuronal Maturation
1 Department of Cell Biology, Cellular and Molecular Basis of Neurodegeneration and Neurorepair, 2 Neurobiology of Development and Regeneration, Institute for Research in Biomedicine and Department of Cell Biology, Barcelona Science Park, University of Barcelona, Josep Samitier 1-5, 08028 Barcelona, Spain, 3 Department of Neurosciences, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0691, USA
Address correspondence to Ana Mingorance-Le Meur and José A. del Rio PhD, Department of Cellular and Physiological Sciences, University of British Columbia–Life Sciences Institute, 2350 Health Sciences Mall, Vancouver, BC V6T 1Z3, Canada. Email: alemeur{at}interchange.ubc.ca.
Nogo-A is a myelin-associated protein expressed by neurons and myelinating mature oligodendrocytes in the central nervous system. Although most research has focused on the participation of Nogo-A in the prevention of axonal regeneration and plasticity in the adult, little attention has been paid to the putative functions of Nogo-A during embryonic development. Here we examined the general pattern and cell-specific distribution of Nogo-A in the prenatal mouse telencephalon. In addition, we studied the development of the major axon tracts and radial and tangential migration in Nogo-A/B/C knockout mice. The pattern of Nogo-A showed distinct distribution in radial glia and postmitotic neurons, in which it is particularly enriched in developing axons. Similarly, Nogo-A was enriched at the leading process of tangentially migrating interneurons but not detectable in radial migrating neurons. Although a low level of Nogo-A appears to be on the surface of many cortical neurons, most proteins have intracellular localization. In Nogo-deficient background, neurons displayed early polarization and increased branching in vitro, probably reflecting a cell-intrinsic role of Nogo proteins in branching reduction, and early tangential migration was delayed. On the basis of these observations, we propose that Nogo proteins, particularly Nogo-A, are involved in multiple processes during cortical development.
Key Words: axon tract • Nogo • radial glia • tangential migration
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  C. Mathis, A. Schroter, M. Thallmair, and M. E. Schwab Nogo-A Regulates Neural Precursor Migration in the Embryonic Mouse Cortex Cereb Cortex, January 21, 2010; (2010): bhp307v1 - bhp307. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Willi, O. Weinmann, C. Winter, J. Klein, R. Sohr, L. Schnell, B. K. Yee, J. Feldon, and M. E. Schwab Constitutive Genetic Deletion of the Growth Regulator Nogo-A Induces Schizophrenia-Related Endophenotypes J. Neurosci., January 13, 2010; 30(2): 556 - 567. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Gil, Z. Bichler, J. K. Lee, O. Seira, F. Llorens, A. Bribian, R. Morales, E. Claverol-Tinture, E. Soriano, L. Sumoy, et al. Developmental Expression of the Oligodendrocyte Myelin Glycoprotein in the Mouse Telencephalon Cereb Cortex, November 5, 2009; (2009) bhp246v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Montani, B. Gerrits, P. Gehrig, A. Kempf, L. Dimou, B. Wollscheid, and M. E. Schwab Neuronal Nogo-A Modulates Growth Cone Motility via Rho-GTP/LIMK1/Cofilin in the Unlesioned Adult Nervous System J. Biol. Chem., April 17, 2009; 284(16): 10793 - 10807. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. L. Cheatwood, A. J. Emerick, M. E. Schwab, and G. L. Kartje Nogo-A Expression After Focal Ischemic Stroke in the Adult Rat Stroke, July 1, 2008; 39(7): 2091 - 2098. [Abstract] [Full Text] [PDF]
|
|