Skip Navigation


Cerebral Cortex Advance Access originally published online on December 26, 2006
Cerebral Cortex 2007 17(10):2346-2353; doi:10.1093/cercor/bhl143
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Supplementary Material
Right arrow All Versions of this Article:
17/10/2346    most recent
bhl143v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Krueger, F.
Right arrow Articles by Grafman, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Krueger, F.
Right arrow Articles by Grafman, J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Published by Oxford University Press 2006.

Event Frequency Modulates the Processing of Daily Life Activities in Human Medial Prefrontal Cortex

Frank Krueger1, Jorge Moll1, Roland Zahn1, Armin Heinecke2 and Jordan Grafman1

1 Cognitive Neuroscience Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892-1440, USA, 2 Brain Innovation B.V., Universiteitssingel 40, 6201 BC Maastricht, The Netherlands

Address correspondence to Jordan Grafman, PhD, Cognitive Neuroscience Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bldg. 10, Room 5C205, MSC 1440, Bethesda, MD 20892-1440, USA. Email: Grafmanj{at}ninds.nih.gov.

Event sequence knowledge is necessary to learn, plan, and perform activities of daily life. Clinical observations suggest that the prefrontal cortex (PFC) is crucial for goal-directed behavior such as carrying out plans, controlling a course of actions, or organizing everyday life routines. Functional neuroimaging studies provide further evidence that the PFC is involved in processing event sequence knowledge, with the medial PFC (Brodmann area 10) primarily engaged in mediating predictable event sequences. However, the exact role of the medial PFC in processing event sequence knowledge depending on the frequency of corresponding daily life activities remains obscure. We used event-related functional magnetic resonance imaging while healthy volunteers judged whether event sequences from high- (HF), moderate- (MF), and low-frequency (LF) daily life activities were correctly ordered. The results demonstrated that different medial PFC subregions were activated depending on frequency. The anterior medial Area 10 was differentially activated for LF and the posterior medial Area 10 for HF activities. We conclude that subregions of the medial PFC are differentially engaged in processing event sequence knowledge depending on how often the activity was reportedly performed in daily life.

Key Words: Brodmann area 10 • event sequence knowledge • fMRI • scripts


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Cereb CortexHome page
R. Zahn, J. Moll, M. Paiva, G. Garrido, F. Krueger, E. D. Huey, and J. Grafman
The Neural Basis of Human Social Values: Evidence from Functional MRI
Cereb Cortex, May 22, 2008; (2008) bhn080v1.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.