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Cerebral Cortex Advance Access originally published online on February 15, 2006
Cerebral Cortex 2007 17(1):221-229; doi:10.1093/cercor/bhj140
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© The Author 2006. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Antisaccade Deficit after Inactivation of the Principal Sulcus in Monkeys

Carine Condy1, Nicolas Wattiez1, Sophie Rivaud-Péchoux1, Léon Tremblay1 and Bertrand Gaymard1,2

1 Institut National de la Santé et de la Recherche Médicale U679, Universite Pierre and Marie Curie, 2 Fédération de Neurophysiologie Clinique, Hôpital de la Salpêtrière, 47 Boulevard de l'Hôpital, 75651 Paris cedex 13, France

Address correspondence to Bertrand Gaymard, INSERM U679, Hôpital de la Salpêtrière, 47 Boulevard de l'Hôpital, 75651 Paris cedex 13, France. Email: gaymard{at}ccr.jussieu.fr.

The antisaccade (AS) task, which requires the ability to suppress unwanted reflexive glances, has proven to be a powerful tool for the analysis of executive control. Performing this task activates a large frontoparietal network, but which area is specifically responsible for reflexive saccade (RS) inhibition has not yet been demonstrated. We reversibly inactivated portions of the principal sulcus in 2 monkeys trained to perform AS and RS tasks. Here we show that inactivation of a circumscribed area in the ventral bank of the principal sulcus induced a strong impairment of RS inhibition without affecting RS triggering. Our results are compatible with a partitioning of the principal sulcus into functional subregions, in which a well-delineated area is critically involved in RS suppression.

Key Words: dorsolateral prefrontal cortex • frontal eye field • inhibitory control • muscimol • principal sulcus


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A. Yoshida and M. Tanaka
Enhanced Modulation of Neuronal Activity during Antisaccades in the Primate Globus Pallidus
Cereb Cortex, May 13, 2008; (2008) bhn069v1.
[Abstract] [Full Text] [PDF]


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