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Cerebral Cortex 2006 16(Supplement 1):i162-i167; doi:10.1093/cercor/bhj174
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© The Author 2006. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Regulation of Stroke-Induced Neurogenesis in Adult Brain—Recent Scientific Progress

Zaal Kokaia1,2, Pär Thored2,3, Andreas Arvidsson2,3 and Olle Lindvall2,3

1 Laboratory of Neural Stem Cell Biology, Section of Restorative Neurology, Stem Cell Institute, University Hospital, SE-221 84 Lund, Sweden, 2 Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund, Sweden and 3 Laboratory of Neurogenesis and Cell Therapy, Section of Restorative Neurology, Wallenberg Neuroscience Center, University Hospital, SE-221 84 Lund, Sweden

Address correspondence to Zaal Kokaia, Laboratory of Neural Stem Cell Biology, Section of Restorative Neurology, Stem Cell Institute, University Hospital, SE-221 84 Lund, Sweden. Email: Zaal.Kokaia{at}med.lu.se.

Stroke induced by middle cerebral artery occlusion in adult rodents induces the formation of new neurons in the damaged striatum, a region that normally does not show neurogenesis. Here we describe recent findings on the regulation of neurogenesis after stroke, in particular regarding the duration of the neurogenic response and the influence of age, as well as the molecular mechanisms influencing migration and survival of the new neurons. We also discuss some crucial issues that need to be addressed in the further exploration of this potential self-repair mechanism after damage to the adult brain.

Key Words: migration • neural stem cells • neurogenesis • striatum • stroke • subventricular zone


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