Skip Navigation

Cerebral Cortex 2006 16(Supplement 1):i152-i161; doi:10.1093/cercor/bhk017
This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Martínez-Cerdeño, V.
Right arrow Articles by Kriegstein, A. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Martínez-Cerdeño, V.
Right arrow Articles by Kriegstein, A. R.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2006. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

The Role of Intermediate Progenitor Cells in the Evolutionary Expansion of the Cerebral Cortex

Verónica Martínez-Cerdeño, Stephen C. Noctor and Arnold R. Kriegstein

Department of Neurology and the Institute for Stem Cell and Tissue Biology, University of California—San Francisco, San Francisco, CA 94143, USA

Address correspondence to Verónica Martínez-Cerdeño, Department of Neurology, and the Institute for Stem Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA 94143, USA. Email: vmc{at}ventricular.org.

The vertebrate cerebral cortex varies from the 3-layered dorsal cortex of reptiles to the 6-layered lissencephalic cortex characteristic of rodents and to the 6-layered gyrencephalic cortex typical of carnivores and primates. Distinct developmental mechanisms may have evolved independently to account for the radial expansion that produced the multilayered cortex of mammals and for the tangential expansion of cortical surface area that resulted in gyrencephalic cortex. Recent evidence shows that during the late stages of cortical development, radial glial cells divide asymmetrically in the ventricular zone to generate radial glial cells and intermediate progenitor (IP) cells and that IP cells subsequently divide symmetrically in the subventricular zone to produce multiple neurons. We propose that the evolution of this two-step pattern of neurogenesis played an important role in the amplification of cell numbers underlying the radial and tangential expansion of the cerebral cortex.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Cereb CortexHome page
T. Kowalczyk, A. Pontious, C. Englund, R. A. M. Daza, F. Bedogni, R. Hodge, A. Attardo, C. Bell, W. B. Huttner, and R. F. Hevner
Intermediate Neuronal Progenitors (Basal Progenitors) Produce Pyramidal-Projection Neurons for All Layers of Cerebral Cortex
Cereb Cortex, October 1, 2009; 19(10): 2439 - 2450.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
B. J. Molyneaux, P. Arlotta, R. M. Fame, J. L. MacDonald, K. L. MacQuarrie, and J. D. Macklis
Novel Subtype-Specific Genes Identify Distinct Subpopulations of Callosal Projection Neurons
J. Neurosci., September 30, 2009; 29(39): 12343 - 12354.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
A. F. P. Cheung, S. Kondo, O. Abdel-Mannan, R. A. Chodroff, T. M. Sirey, L. E. Bluy, N. Webber, J. DeProto, S. J. Karlen, L. Krubitzer, et al.
The Subventricular Zone Is the Developmental Milestone of a 6-Layered Neocortex: Comparisons in Metatherian and Eutherian Mammals
Cereb Cortex, September 2, 2009; (2009) bhp168v1.
[Abstract] [Full Text] [PDF]

Home page
 Biol LettHome page
G. F Striedter and C. J Charvet
Telencephalon enlargement by the convergent evolution of expanded subventricular zones
Biol Lett, February 23, 2009; 5(1): 134 - 137.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Microbiol. Rev.Home page
M. C.-J. Cheeran, J. R. Lokensgard, and M. R. Schleiss
Neuropathogenesis of Congenital Cytomegalovirus Infection: Disease Mechanisms and Prospects for Intervention
Clin. Microbiol. Rev., January 1, 2009; 22(1): 99 - 126.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
J. L. Fish, C. Dehay, H. Kennedy, and W. B. Huttner
Making bigger brains-the evolution of neural-progenitor-cell division
J. Cell Sci., September 1, 2008; 121(17): 2783 - 2793.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
B. Cubelos, A. Sebastian-Serrano, S. Kim, C. Moreno-Ortiz, J. M. Redondo, C. A. Walsh, and M. Nieto
Cux-2 Controls the Proliferation of Neuronal Intermediate Precursors of the Cortical Subventricular Zone
Cereb Cortex, August 1, 2008; 18(8): 1758 - 1770.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
Z. Mo and N. Zecevic
Is Pax6 Critical for Neurogenesis in the Human Fetal Brain?
Cereb Cortex, June 1, 2008; 18(6): 1455 - 1465.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
C. Metin, C. Alvarez, D. Moudoux, T. Vitalis, C. Pieau, and Z. Molnar
Conserved pattern of tangential neuronal migration during forebrain development
Development, August 1, 2007; 134(15): 2815 - 2827.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
C. V. Pfenninger, T. Roschupkina, F. Hertwig, D. Kottwitz, E. Englund, J. Bengzon, S. E. Jacobsen, and U. A. Nuber
CD133 Is Not Present on Neurogenic Astrocytes in the Adult Subventricular Zone, but on Embryonic Neural Stem Cells, Ependymal Cells, and Glioblastoma Cells
Cancer Res., June 15, 2007; 67(12): 5727 - 5736.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
Z. Mo, A. R. Moore, R. Filipovic, Y. Ogawa, I. Kazuhiro, S. D. Antic, and N. Zecevic
Human Cortical Neurons Originate from Radial Glia and Neuron-Restricted Progenitors
J. Neurosci., April 11, 2007; 27(15): 4132 - 4145.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.