Cerebral Cortex Advance Access originally published online on September 8, 2005
Cerebral Cortex 2006 16(7):929-940; doi:10.1093/cercor/bhj034
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Activity-dependent Expression of occ1 in Excitatory Neurons Is a Characteristic Feature of the Primate Visual Cortex
1 Division of Brain Biology, National Institute for Basic Biology, Aichi 444-8585, Japan, 2 Department of Basic Biology, The Graduate University for Advanced Studies, Aichi 444-8585, Japan and 3 Laboratory for Neural Architecture, Brain Science Institute, RIKEN, Saitama 351-0198, Japan, 4 Present address: Genome Exploration Research Group, Genomic Sciences Center, RIKEN, Kanagawa, 230-0045, Japan
Address correspondence to Tetsuo Yamamori, Division of Brain Biology, National Institute for Basic Biology, 38 Nishigonaka, Myodaijicho, Okazaki, Aichi 444-8585, Japan. Email: yamamori{at}nibb.ac.jp.
occ1 is a gene whose expression is particularly abundant in neurons in the macaque primary visual cortex (V1). In the present study, we report that the expression of occ1 mRNA in the macaque neocortex can be classified into two modes. The first mode is associated with excitatory neurons distributed in the major thalamocortical recipient layers that exhibit strong cytochrome oxidase activity. This is highly prominent in V1. The second mode is associated with parvalbumin-positive GABAergic interneurons and is distributed across the macaque neocortex. In V1, monocular deprivation showed that occ1 mRNA expression in excitatory neurons was markedly dependent on afferent activity, whereas that in GABAergic interneurons was not. Cross-species comparison showed specific differences in expression. In marmosets, a strong expression was observed in V1 similarly to macaques. The occ1 mRNA expression, however, was generally weak in the mouse neocortex. In rabbit and ferret cortices, the strong expression was observed only in GABAergic interneurons. We conclude that activity-dependent occ1 mRNA expression in the excitatory neurons of V1 was caused by a novel mechanism acquired by primates after their separation from other lineages.
Key Words: brain evolution • in situ hybridization • Macaca fuscata • TSC-36 • V1-specific
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  T. Sasaki, Y. Komatsu, A. Watakabe, K. Sawada, and T. Yamamori Prefrontal-Enriched SLIT1 Expression in Old World Monkey Cortex Established during the Postnatal Development Cereb Cortex, February 1, 2010; (2010): bhp319v1 - bhp319. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Takaji, Y. Komatsu, A. Watakabe, T. Hashikawa, and T. Yamamori Paraneoplastic Antigen-Like 5 Gene (PNMA5) Is Preferentially Expressed in the Association Areas in a Primate Specific Manner Cereb Cortex, December 1, 2009; 19(12): 2865 - 2879. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Watakabe, Y. Komatsu, O. Sadakane, S. Shimegi, T. Takahata, N. Higo, S. Tochitani, T. Hashikawa, T. Naito, H. Osaki, et al. Enriched Expression of Serotonin 1B and 2A Receptor Genes in Macaque Visual Cortex and their Bidirectional Modulatory Effects on Neuronal Responses Cereb Cortex, August 1, 2009; 19(8): 1915 - 1928. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Takahata, Y. Komatsu, A. Watakabe, T. Hashikawa, S. Tochitani, and T. Yamamori Differential Expression Patterns of occ1-Related Genes in Adult Monkey Visual Cortex Cereb Cortex, August 1, 2009; 19(8): 1937 - 1951. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Takahata, N. Higo, J. H. Kaas, and T. Yamamori Expression of immediate-early genes reveals functional compartments within ocular dominance columns after brief monocular inactivation PNAS, July 21, 2009; 106(29): 12151 - 12155. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Watakabe, N. Ichinohe, S. Ohsawa, T. Hashikawa, Y. Komatsu, K. S. Rockland, and T. Yamamori Comparative Analysis of Layer-Specific Genes in Mammalian Neocortex Cereb Cortex, August 1, 2007; 17(8): 1918 - 1933. [Abstract] [Full Text] [PDF]
|
|