Cerebral Cortex Advance Access originally published online on July 13, 2005
Cerebral Cortex 2006 16(4):500-508; doi:10.1093/cercor/bhi129
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Mistaking a House for a Face: Neural Correlates of Misperception in Healthy Humans
1 Department of Psychology, Columbia University, 406 Schermerhorn Hall, 1190 Amsterdam Ave, New York, NY 10027, USA and 2 Functional MRI Research Center, Department of Psychiatry and Radiology, Columbia University Neurological Institute Box 108 710 West 168th Street, New York, NY 10032, USA
Address correspondence to C. Summerfield, Department of Psychology, Columbia University, 406 Schermerhorn Hall, 1190 Amsterdam Ave, New York, NY 10027, USA. Email: summerfd{at}paradox.columbia.edu.
Individuals with normal vision can sometimes momentarily mistake one object for another. In this functional magnetic resonance imaging study, we investigated how extrastriate visual regions respond during these erroneous perceptual judgements. Subjects were asked to discriminate images of houses and faces that were degraded such that they were close to an individually defined threshold for perception. On correct trials, voxels localized on the inferior occipital (OFA), fusiform (FFA) and parahippocampal (PPA) gyri exhibited selectivity for face and house images as expected. On incorrect trials, no face- or place-selectivity was observed for OFA or PPA. However, consistent with ‘predictive coding’ accounts of perception, we observed that the FFA also responded robustly on trials where a house was misperceived as a face, and concurrent activation was observed in medio-frontal and right parietal regions previously implicated in decision making under uncertainty. We suggest that FFA responses during misperception may be driven by a predictive top-down signal from these regions.
Key Words: extrastriate • misperception • neural correlates • predictive coding • visual regions
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