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Cerebral Cortex Advance Access originally published online on April 20, 2005
Cerebral Cortex 2006 16(1):76-82; doi:10.1093/cercor/bhi085
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© The Author 2005. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oupjournals.org

Modulation of Antisaccades by Transcranial Magnetic Stimulation of the Human Frontal Eye Field

Bettina Olk1, Erik Chang2, Alan Kingstone3 and Tony Ro2

1 School of Humanities and Social Sciences, International University Bremen, Bremen, Germany, 2 Department of Psychology, Rice University, Houston, TX, USA and 3 Department of Psychology, University of British Columbia, Vancouver, Canada

Address correspondence to Bettina Olk, International University Bremen, School of Humanities and Social Sciences, P.O. Box 750561, 28725 Bremen, Germany. Email: b.olk{at}iu-bremen.de.

It has been suggested that the frontal eye field (FEF), which is involved with the inhibition and generation of saccades, is engaged to a different degree in pro- and antisaccades. Pro- and antisaccades are often assessed in separate experimental blocks. In such cases, saccade inhibition is required for antisaccades but not for prosaccades. To more directly assess the role of the FEF in saccade inhibition and generation, a new paradigm was used in which inhibition was necessary on pro- and antisaccade trials. Participants looked in the direction indicated by a target (‘<’ or ‘>’) that appeared in the left or right visual field. When the pointing direction and the location were congruent, prosaccades were executed; otherwise antisaccades were required. Saccadic latencies were measured in blocks without and with single pulse transcranial magnetic stimulation (TMS) to the right FEF or a right posterior control site. Results showed that antisaccades generated into the hemifield ipsilateral to the TMS were significantly delayed after TMS over the FEF, but not the posterior control site. This result is interpreted in terms of a modulation of saccade inhibition to the contralateral visual field due to disruption of processing in the FEF.

Key Words: eye movements • inhibition • reflexive saccades • TMS • voluntary saccades


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S. L. Prime, M. Vesia, and J. D. Crawford
TMS Over Human Frontal Eye Fields Disrupts Trans-saccadic Memory of Multiple Objects
Cereb Cortex, July 29, 2009; (2009) bhp148v1.
[Abstract] [Full Text] [PDF]


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