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Cerebral Cortex Advance Access originally published online on December 8, 2004
Cerebral Cortex 2005 15(8):1134-1145; doi:10.1093/cercor/bhh213
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© Oxford University Press 2004; all rights reserved

A role of MAP1B in Reelin-dependent Neuronal Migration

Christian González-Billault1,3, José A. Del Río2, Jesús M. Ureña2, Eva M. Jiménez-Mateos1, María J. Barallobre2, Marta Pascual2, Lluís Pujadas2, Sergi Simó2, Anna La Torre2, Rosalina Gavin2, Francisco Wandosell1, Eduardo Soriano2 and Jesús Ávila1

1 Centro de Biología Molecular, Universidad Autonoma de Madrid-CSIC, Madrid 28049, Spain, 2 IRBB-Barcelona Science Park and Department of Cell Biology, University of Barcelona, Barcelona 08028, Spain, 3 Present address: Department of Biology and Millennium Institute for Advanced Studies in Cell Biology and Biotechnology (CBB), Faculty of Sciences, Universidad de Chile, Las Palmeras 3425, Ñuñoa, Santiago, Chile

Address correspondence to either Jesus Avila, Centro de Biologia Molecular Severo Ochoa, CSIC-UAM, Cantonblanco 28049, Madrid, Spain. Email: javila{at}cbm.uam.es. Or Eduardo Soriano, IRBB-Parc Científic de Barcelona, Cell and Developmental Biology Programme, University of Barcelona, Josep Samitier 1–5, Barcelona 08028, Spain. Email: esoriano{at}pcb.ub.es.

The signaling cascades governing neuronal migration are believed to link extracellular signals to cytoskeletal components. MAP1B is a neuron-specific microtubule-associated protein implicated in the control of the dynamic stability of microtubules and in the cross-talk between microtubules and actin filaments. Here we show that Reelin can induce mode I MAP1B phosphorylation, both in vivo and in vitro, through gsk3 and cdk5 activation. Additionally, mDab1 participates in the signaling cascade responsible for mode I MAP1B phosphorylation. Conversely, MAP1B-deficient mice display an abnormal structuring of the nervous system, especially in brain laminated areas, indicating a failure in neuronal migration. Therefore, we propose that Reelin can induce post-translational modifications on MAP1B that could correlate with its function in neuronal migration.

Key Words: cyclin-dependent kinase 5 • glycogen synthase kinase 3 • microtubule-associated protein • neuronal migration • Reelin


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