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Cerebral Cortex Advance Access originally published online on February 23, 2005
Cerebral Cortex 2005 15(11):1723-1735; doi:10.1093/cercor/bhi049
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© The Author 2005. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oupjournals.org

Selecting Among Competing Alternatives: Selection and Retrieval in the Left Inferior Frontal Gyrus

H.E. Moss1, S. Abdallah1, P. Fletcher2, P. Bright1, L. Pilgrim1, K. Acres1 and L.K. Tyler1

1 Department of Experimental Psychology, University of Cambridge, UK and 2 Department of Psychiatry, University of Cambridge, UK

Address correspondence to Helen E. Moss, Centre for Speech and Language, Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK. Email: hem10{at}cam.ac.uk.

It has been widely argued that the left inferior frontal gyrus (LIFG) is involved in the control of retrieval of information from long-term memory. Recent claims that the LIFG is involved in selecting among semantic alternatives have been challenged on the grounds that the manipulation of selection demands may have been confounded with controlled retrieval. The current study used an event-related functional magnetic resonance paradigm to re-examine the possibility that LIFG activation is involved in selection processes. In order to minimize potential confounding effects of controlled retrieval, we used an automatic retrieval task (picture naming) and held retrieval demands constant, while varying selection demands by way of competitor priming from earlier semantically related trials. We found significant activation in LIFG as a function of increased selection demands; activation centred on two peaks, one in anterior LIFG and a second more superior and posterior region. These data support the view that LIFG plays a role in selection among semantic information, even in the absence of controlled retrieval processes.

Key Words: competition • LIFG • retrieval • selection • semantic


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