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Cerebral Cortex Advance Access originally published online on January 19, 2005
Cerebral Cortex 2005 15(10):1497-1509; doi:10.1093/cercor/bhi028
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© Oxford University Press 2005; all rights reserved

Isofrequency Band-like Zones of Activation Revealed by Optical Imaging of Intrinsic Signals in the Cat Primary Auditory Cortex

H. Ojima1, M. Takayanagi2, D. Potapov1 and R. Homma3

1 Cortical Organization Systematics, BSI, RIKEN, 2-1 Hirosawa, Wako, Saitama, 351-0198 Japan, 2 1st Department of Anatomy, Toho University School of Medicine, Toho, 5-21-16, Omori Nishi, Ota-ku, Tokyo, 143-8540, Japan and 3 Integrative Neural Systems, BSI, RIKEN, 2-1 Hirosawa, Wako, Saitama, 351-0198 Japan

Address corresponding to Hisayuki Ojima, Cortical Organization and Systematics, BSI, RIKEN, 2-1 Hirosawa, Wako, Saitama, 351-0198 Japan. Email: yojima{at}brain.riken.jp.

Neurons of similar frequency preference are arranged in isofrequency bands (IFBs) across the primary auditory cortex (AI) of many mammals. Across the AI of the cat, one of the most frequently studied species for auditory anatomy and function, we demonstrate IFB-like responses using optical imaging of intrinsic signals (OIS). Optically defined activations were extensively elongated along the dorsoventral axis of AI (the ratio of the major and minor axes was ~2:1), and systematically shifted as a function of stimulus frequency. The elongation of this IFB-like zone was more conspicuous at higher frequencies. In the ventral sector of the imaged field, the IFB-like zones of activation evoked at different pure tone frequencies tended to overlap extensively. Electrophysiological recording from loci within the optically defined zones of activation revealed matched responses to the frequencies used for optical imaging at 65% of these loci. The dorsoventral orientation of these zones of activation was also closely matched with the orientation of tangentially spreading intrinsic axon terminals, as revealed anatomically. The visualization of IFB-like architecture and tonotopic organization by OIS provides a basic framework for investigating the relationships of different spectral channels and between multiple acoustic parameters at a neuronal population level.

Key Words: anterograde tracer • convergence • frequency tuning • horizontal connections • tonotopy


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