Skip Navigation


Cerebral Cortex Advance Access originally published online on April 27, 2004
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
14/9/966    most recent
bhh057v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (47)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Tisserand, D. J.
Right arrow Articles by Jolles, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tisserand, D. J.
Right arrow Articles by Jolles, J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Cerebral Cortex September 2004; 14:966-973
© Oxford University Press 2004

Article

A Voxel-based Morphometric Study to Determine Individual Differences in Gray Matter Density Associated with Age and Cognitive Change Over Time

Danielle J. Tisserand1, Martin P.J. van Boxtel2, Jens C. Pruessner3, Paul Hofman4, Alan C. Evans3 and Jelle Jolles2

1 Rotman Research Institute, Baycrest Centre for Geriatric Care, Toronto, Canada, 2 Brain & Behaviour Institute, Maastricht University, The Netherlands, 3 Montreal Neurological Institute, McGill University, Canada, 4 Department of Radiology, University Hospital Maastricht, The Netherlands

Voxel-based morphometry (VBM) was used to examine the relation between age and gray matter density cross-sectionally and to study the association between gray matter density and longitudinal decline in performance on cognitive tests in healthy, non-demented elderly individuals. Participants were neuropsychologically tested at baseline and again after 3 years. Thirty-seven subjects (mean age 72.5 years) who showed a decline in cognitive test performance at follow-up were compared with 38 individually matched control subjects (mean age 71.8 years) whose performance did not change over time. Magnetic resonance imaging scans were acquired at follow-up and individual differences in regional gray matter density were examined with VBM. The largest age effects were found in various regions in the prefrontal cortex, the (medial) temporal lobes and the striate cortex. Longitudinal cognitive decline was associated with decreased gray matter density in prefrontal areas, the (medial) temporal lobes and the posterior parietal cortex. These findings suggest that prefrontal and temporal cortical regions are of particular relevance both in aging and age-related cognitive decline in healthy elderly individuals.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Cereb CortexHome page
R. Hester, N. Barre, K. Murphy, T. J. Silk, and J. B. Mattingley
Human Medial Frontal Cortex Activity Predicts Learning from Errors
Cereb Cortex, August 1, 2008; 18(8): 1933 - 1940.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
N. Raz, U. Lindenberger, P. Ghisletta, K. M. Rodrigue, K. M. Kennedy, and J. D. Acker
Neuroanatomical Correlates of Fluid Intelligence in Healthy Adults and Persons with Vascular Risk Factors
Cereb Cortex, March 1, 2008; 18(3): 718 - 726.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
B. H. Schott, L. Niehaus, B. C. Wittmann, H. Schutze, C. I. Seidenbecher, H.-J. Heinze, and E. Duzel
Ageing and early-stage Parkinson's disease affect separable neural mechanisms of mesolimbic reward processing
Brain, September 1, 2007; 130(9): 2412 - 2424.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. Kuchinad, P. Schweinhardt, D. A. Seminowicz, P. B. Wood, B. A. Chizh, and M. C. Bushnell
Accelerated Brain Gray Matter Loss in Fibromyalgia Patients: Premature Aging of the Brain?
J. Neurosci., April 11, 2007; 27(15): 4004 - 4007.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
A. J. Saykin, H. A. Wishart, L. A. Rabin, R. B. Santulli, L. A. Flashman, J. D. West, T. L. McHugh, and A. C. Mamourian
Older adults with cognitive complaints show brain atrophy similar to that of amnestic MCI.
Neurology, September 12, 2006; 67(5): 834 - 842.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
P. Dazzan, K. D. Morgan, X. Chitnis, J. Suckling, C. Morgan, P. Fearon, P. K. McGuire, P. B. Jones, J. Leff, and R. M. Murray
The Structural Brain Correlates of Neurological Soft Signs in Healthy Individuals
Cereb Cortex, August 1, 2006; 16(8): 1225 - 1231.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
R. Dorsaint-Pierre, V. B. Penhune, K. E. Watkins, P. Neelin, J. P. Lerch, M. Bouffard, and R. J. Zatorre
Asymmetries of the planum temporale and Heschl's gyrus: relationship to language lateralization
Brain, May 1, 2006; 129(5): 1164 - 1176.
[Abstract] [Full Text] [PDF]

Home page
 Journals of Gerontology Series A: Biological Sciences and Medical SciencesHome page
A. J. Ross, P. S. Sachdev, W. Wen, and H. Brodaty
Longitudinal changes during aging using proton magnetic resonance spectroscopy.
J. Gerontol. A Biol. Sci. Med. Sci., March 1, 2006; 61(3): 291 - 298.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
N. Raz, U. Lindenberger, K. M. Rodrigue, K. M. Kennedy, D. Head, A. Williamson, C. Dahle, D. Gerstorf, and J. D. Acker
Regional Brain Changes in Aging Healthy Adults: General Trends, Individual Differences and Modifiers
Cereb Cortex, November 1, 2005; 15(11): 1676 - 1689.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
M. N. Rajah and M. D'Esposito
Region-specific changes in prefrontal function with age: a review of PET and fMRI studies on working and episodic memory
Brain, September 1, 2005; 128(9): 1964 - 1983.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.