Cerebral Cortex April 2004; 14:410-423
© Oxford University Press 2004
Article |
Differential Vulnerability of Anterior White Matter in Nondemented Aging with Minimal Acceleration in Dementia of the Alzheimer Type: Evidence from Diffusion Tensor Imaging
1 Howard Hughes Medical Institute, Washington University, St Louis, MO, USA, 2 Department of Psychology, Washington University, St Louis, MO, USA, 3 Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO, USA, 4 Department of Anatomy & Neurobiology,Washington University School of Medicine, St Louis, MO, USA, 5 Department of Neurology, Washington University School of Medicine, St Louis, MO, USA
White matter microstructural integrity was assessed using diffusion tensor imaging (DTI) in 25 young adults, 25 nondemented older adults, and 25 age-matched older adults with dementia of the Alzheimer type (DAT). For each individual, measures of anisotropy and diffusivity were obtained from atlas-transformed images in the anterior and posterior callosum and in the frontal, parietal, temporal and occipital white matter. These data revealed age differences in anisotropy and diffusivity in all assessed regions. Age effects were greater in the anterior as opposed to the posterior corpus callosum and greater in the frontal white matter than in the temporal, parietal and occipital white matter, suggesting age-associated differences in white matter that exhibit a roughly anterior-to-posterior gradient. In contrast, individuals with early-stage dementia exhibited minimal, if any, additional change in anterior regions but did show greater deterioration of white matter in posterior lobar regions. Taken collectively, these results indicate that nondemented aging is characterized by significant changes in white matter most prominently in anterior brain regions. The dissociation between the regional effects of age and dementia status suggests that the mechanisms underlying age-associated cognitive decline are likely distinct from those underlying DAT.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  E. D. Boorman and J. Sallet Mean-Variance or Prospect Theory? The Nature of Value Representations in the Human Brain J. Neurosci., June 24, 2009; 29(25): 7945 - 7947. [Full Text] [PDF]
|
|
|
|
 |
|
 L. Wang, F.C. Goldstein, E. Veledar, A.I. Levey, J.J. Lah, C.C. Meltzer, C.A. Holder, and H. Mao Alterations in Cortical Thickness and White Matter Integrity in Mild Cognitive Impairment Measured by Whole-Brain Cortical Thickness Mapping and Diffusion Tensor Imaging AJNR Am. J. Neuroradiol., May 1, 2009; 30(5): 893 - 899. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. T. Westlye, K. B. Walhovd, A. Bjornerud, P. Due-Tonnessen, and A. M. Fjell Error-Related Negativity is Mediated by Fractional Anisotropy in the Posterior Cingulate Gyrus--A Study Combining Diffusion Tensor Imaging and Electrophysiology in Healthy Adults Cereb Cortex, February 1, 2009; 19(2): 293 - 304. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. B. Parente, E. L. Gasparetto, L. C. H. d. Cruz Jr., R. C. Domingues, A. C. Baptista, A. C. P. Carvalho, and R. C. Domingues Potential Role of Diffusion Tensor MRI in the Differential Diagnosis of Mild Cognitive Impairment and Alzheimer's Disease Am. J. Roentgenol., May 1, 2008; 190(5): 1369 - 1374. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Stadlbauer, E. Salomonowitz, G. Strunk, T. Hammen, and O. Ganslandt Age-related Degradation in the Central Nervous System: Assessment with Diffusion-Tensor Imaging and Quantitative Fiber Tracking Radiology, April 1, 2008; 247(1): 179 - 188. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. C. Putnam, G. S. Wig, S. T. Grafton, W. M. Kelley, and M. S. Gazzaniga Structural Organization of the Corpus Callosum Predicts the Extent and Impact of Cortical Activity in the Nondominant Hemisphere J. Neurosci., March 12, 2008; 28(11): 2912 - 2918. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. E. Hugenschmidt, A. M. Peiffer, R. A. Kraft, R. Casanova, A. R. Deibler, J. H. Burdette, J. A. Maldjian, and P. J. Laurienti Relating Imaging Indices of White Matter Integrity and Volume in Healthy Older Adults Cereb Cortex, February 1, 2008; 18(2): 433 - 442. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E V SULLIVAN and A PFEFFERBAUM Neuroradiological characterization of normal adult ageing Br. J. Radiol., December 1, 2007; 80(Special_Issue_2): S99 - S108. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Sydykova, R. Stahl, O. Dietrich, M. Ewers, M. F. Reiser, S. O. Schoenberg, H.-J. Moller, H. Hampel, and S. J. Teipel Fiber Connections between the Cerebral Cortex and the Corpus Callosum in Alzheimer's Disease: A Diffusion Tensor Imaging and Voxel-Based Morphometry Study Cereb Cortex, October 1, 2007; 17(10): 2276 - 2282. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Minati, M. Grisoli, and M. G. Bruzzone MR Spectroscopy, Functional MRI, and Diffusion-Tensor Imaging in the Aging Brain: A Conceptual Review J Geriatr Psychiatry Neurol, March 1, 2007; 20(1): 3 - 21. [Abstract] [PDF]
|
|
|
|
 |
|
 Y. Zhang, N. Schuff, G. -H. Jahng, W. Bayne, S. Mori, L. Schad, S. Mueller, A. -T. Du, J. H. Kramer, K. Yaffe, et al. Diffusion tensor imaging of cingulum fibers in mild cognitive impairment and Alzheimer disease Neurology, January 2, 2007; 68(1): 13 - 19. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Pfefferbaum, M. J. Rosenbloom, E. Adalsteinsson, and E. V. Sullivan Diffusion tensor imaging with quantitative fibre tracking in HIV infection and alcoholism comorbidity: synergistic white matter damage Brain, January 1, 2007; 130(1): 48 - 64. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Yoshita, E. Fletcher, D. Harvey, M. Ortega, O. Martinez, D. M. Mungas, B. R. Reed, and C. S. DeCarli Extent and distribution of white matter hyperintensities in normal aging, MCI, and AD Neurology, December 26, 2006; 67(12): 2192 - 2198. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Wingfield and M. Grossman Language and the Aging Brain: Patterns of Neural Compensation Revealed by Functional Brain Imaging J Neurophysiol, December 1, 2006; 96(6): 2830 - 2839. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Ramani, J. H. Jensen, and J. A. Helpern Quantitative MR Imaging in Alzheimer Disease Radiology, October 1, 2006; 241(1): 26 - 44. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N Nakayama, A Okumura, J Shinoda, Y-T Yasokawa, K Miwa, S-I Yoshimura, and T Iwama Evidence for white matter disruption in traumatic brain injury without macroscopic lesions J. Neurol. Neurosurg. Psychiatry, July 1, 2006; 77(7): 850 - 855. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Persson, L. Nyberg, J. Lind, A. Larsson, L.-G. Nilsson, M. Ingvar, and R. L. Buckner Structure-Function Correlates of Cognitive Decline in Aging Cereb Cortex, July 1, 2006; 16(7): 907 - 915. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. V. Sullivan, E. Adalsteinsson, and A. Pfefferbaum Selective Age-related Degradation of Anterior Callosal Fiber Bundles Quantified In Vivo with Fiber Tracking Cereb Cortex, July 1, 2006; 16(7): 1030 - 1039. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. H. Salat, E. E. Smith, D. S. Tuch, T. Benner, V. Pappu, K. M. Schwab, M. E. Gurol, H. D. Rosas, J. Rosand, and S. M. Greenberg White Matter Alterations in Cerebral Amyloid Angiopathy Measured by Diffusion Tensor Imaging Stroke, July 1, 2006; 37(7): 1759 - 1764. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Xie, J. X. Xiao, G. L. Gong, Y. F. Zang, Y. H. Wang, H. K. Wu, and X. X. Jiang Voxel-based detection of white matter abnormalities in mild Alzheimer disease Neurology, June 27, 2006; 66(12): 1845 - 1849. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Taoka, S. Iwasaki, M. Sakamoto, H. Nakagawa, A. Fukusumi, K. Myochin, S. Hirohashi, T. Hoshida, and K. Kichikawa Diffusion anisotropy and diffusivity of white matter tracts within the temporal stem in Alzheimer disease: evaluation of the "tract of interest" by diffusion tensor tractography. AJNR Am. J. Neuroradiol., May 1, 2006; 27(5): 1040 - 1045. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Persson, J. Lind, A. Larsson, M. Ingvar, M. Cruts, C. Van Broeckhoven, R. Adolfsson, L. -G. Nilsson, and L. Nyberg Altered brain white matter integrity in healthy carriers of the APOE {varepsilon}4 allele: A risk for AD? Neurology, April 11, 2006; 66(7): 1029 - 1033. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. J. Deary, M. E. Bastin, A. Pattie, J. D. Clayden, L. J. Whalley, J. M. Starr, and J. M. Wardlaw White matter integrity and cognition in childhood and old age Neurology, February 28, 2006; 66(4): 505 - 512. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R Peters Ageing and the brain Postgrad. Med. J., February 1, 2006; 82(964): 84 - 88. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. A. Charlton, T. R. Barrick, D. J. McIntyre, Y. Shen, M. O'Sullivan, F. A. Howe, C. A. Clark, R. G. Morris, and H. S. Markus White matter damage on diffusion tensor imaging correlates with age-related cognitive decline Neurology, January 24, 2006; 66(2): 217 - 222. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Burns, J. A. Church, D. K. Johnson, C. Xiong, D. Marcus, A. F. Fotenos, A. Z. Snyder, J. C. Morris, and R. L. Buckner White Matter Lesions Are Prevalent but Differentially Related With Cognition in Aging and Early Alzheimer Disease Arch Neurol, December 1, 2005; 62(12): 1870 - 1876. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Raz, U. Lindenberger, K. M. Rodrigue, K. M. Kennedy, D. Head, A. Williamson, C. Dahle, D. Gerstorf, and J. D. Acker Regional Brain Changes in Aging Healthy Adults: General Trends, Individual Differences and Modifiers Cereb Cortex, November 1, 2005; 15(11): 1676 - 1689. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Schulte, E.V. Sullivan, E.M. Muller-Oehring, E. Adalsteinsson, and A. Pfefferbaum Corpus Callosal Microstructural Integrity Influences Interhemispheric Processing: A Diffusion Tensor Imaging Study Cereb Cortex, September 1, 2005; 15(9): 1384 - 1392. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. S. Tuch, D. H. Salat, J. J. Wisco, A. K. Zaleta, N. D. Hevelone, and H. D. Rosas Choice reaction time performance correlates with diffusion anisotropy in white matter pathways supporting visuospatial attention PNAS, August 23, 2005; 102(34): 12212 - 12217. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Head, A. Z. Snyder, L. E. Girton, J. C. Morris, and R. L. Buckner Frontal-Hippocampal Double Dissociation Between Normal Aging and Alzheimer's Disease Cereb Cortex, June 1, 2005; 15(6): 732 - 739. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. F. Fotenos, A. Z. Snyder, L. E. Girton, J. C. Morris, and R. L. Buckner Normative estimates of cross-sectional and longitudinal brain volume decline in aging and AD Neurology, March 22, 2005; 64(6): 1032 - 1039. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Choi, K. O. Lim, I. Monteiro, and B. Reisberg Diffusion Tensor Imaging of Frontal White Matter Microstructure in Early Alzheimer's Disease: A Preliminary Study J Geriatr Psychiatry Neurol, March 1, 2005; 18(1): 12 - 19. [Abstract] [PDF]
|
|