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Cerebral Cortex April 2004; 14:404-409
© Oxford University Press 2004

Article

Prefrontal Cortex Asymmetry for Memory Encoding of Words and Abstract Shapes

Agnes Floel1,2, David Poeppel3, Elizabeth A. Buffalo4, Allen Braun5, Carolyn W.-H. Wu1, Hyae-Jung Seo1, Katja Stefan1, Stefan Knecht2 and Leonardo G. Cohen1

1 Human Cortical Physiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health (NIH), Bethesda, MD, USA, 2 Department of Neurology, University of Münster, Münster, Germany, 3 Department of Linguistics and Department of Biology, University of Maryland, College Park, MD, USA, 4 Laboratory of Neuropsychology, National Institute of Mental Health, NIH, Bethesda, MD, USA, 5 Voice, Speech and Language Branch, National Institute of Deafness and other Communication Disorders, NIH, Bethesda, MD, USA

Previous work suggested a differential contribution of prefrontal cortex (PFC) to successful encoding depending on the stimulus material. Here, we tested the hypothesis that encoding of words preferentially involves the left PFC, while encoding of nonverbal items (abstract shapes) relies on the right PFC. We used an experimental design that evaluated encoding of both words and abstract shapes in the same healthy volunteers. A transient virtual lesion of the left or the right PFC was elicited with transcranial magnetic stimulation (TMS) while subjects memorized verbal and nonverbal items. We found that encoding of verbal material was disrupted by left PFC stimulation, whereas encoding of nonverbal material was disrupted by right PFC stimulation. These results demonstrate a functionally relevant lateralization of prefrontal contribution for verbal and nonverbal memory encoding.


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