Cerebral Cortex February 2004; 14:143-155
© Oxford University Press 2004
Age-related Changes in Neural Activity during Visual Target Detection Measured by fMRI
1 Center for the Study of Aging and Human Development, Duke University Medical Center, Durham, NC 27710, USA, 2 Brain Imaging and Analysis Center, Duke University Medical Center, Durham, NC 27710, USA, 3 Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA, 4 Department of Radiology, Duke University Medical Center, Durham, NC 27710, USA
We used functional magnetic resonance imaging (fMRI) of a visual target detection (oddball) task to investigate age differences in neural activation for the detection of two types of infrequent events: visually simple items requiring a response shift (targets) and visually complex items that did not entail a response shift (novels). Targets activated several prefrontal regions (e.g. middle frontal gyrus), as well as deep gray matter regions (caudate, putamen, thalamus and insula). Prefrontal activation was similar for younger and older adults, whereas deep gray matter activation was relatively greater for the older adults. Novels activated occipital regions (fusiform and lateral occipital gyri), and this activation was relatively reduced for older adults. The changes in behavioral performance across the task conditions were similar for the two age groups, although the older adults’ responses were slower overall. Regression analyses of the relation between neural activation and task performance (response time) indicated that whereas performance was mediated most directly by prefrontal cortex for younger adults, older adults’ performance was influenced to a greater extent by deep gray matter structures. Older adults may place relatively greater emphasis on the attentional control of response regulation, in compensation for the age-related decline in visual processing efficiency.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  T. M. C. Lee, A. W. S. Leung, P. T. Fox, J.-H. Gao, and C. C. H. Chan Age-related differences in neural activities during risk taking as revealed by functional MRI Soc Cogn Affect Neurosci, March 1, 2008; 3(1): 7 - 15. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. L. GRADY Cognitive Neuroscience of Aging Ann. N.Y. Acad. Sci., March 1, 2008; 1124(1): 127 - 144. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Soei and I. Daum Course of relational and non-relational recognition memory across the adult lifespan Learn. Mem., January 3, 2008; 15(1): 21 - 28. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Heuninckx, N. Wenderoth, and S. P. Swinnen Systems Neuroplasticity in the Aging Brain: Recruiting Additional Neural Resources for Successful Motor Performance in Elderly Persons J. Neurosci., January 2, 2008; 28(1): 91 - 99. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Minati, M. Grisoli, and M. G. Bruzzone MR Spectroscopy, Functional MRI, and Diffusion-Tensor Imaging in the Aging Brain: A Conceptual Review J Geriatr Psychiatry Neurol, March 1, 2007; 20(1): 3 - 21. [Abstract] [PDF]
|
|
|
|
 |
|
 K. R. Daffner, K. K. Ryan, D. M. Williams, A. E. Budson, D. M. Rentz, D. A. Wolk, and P. J. Holcomb Increased Responsiveness to Novelty is Associated with Successful Cognitive Aging. J. Cogn. Neurosci., October 1, 2006; 18(10): 1759 - 1773. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Crottaz-Herbette and V. Menon Where and when the anterior cingulate cortex modulates attentional response: combined fMRI and ERP evidence. J. Cogn. Neurosci., May 1, 2006; 18(5): 766 - 780. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. P. Walker, R. Stickgold, F. A. Jolesz, and S.-S. Yoo The Functional Anatomy of Sleep-dependent Visual Skill Learning Cereb Cortex, November 1, 2005; 15(11): 1666 - 1675. [Abstract] [Full Text] [PDF]
|
|