Cerebral Cortex Advance Access originally published online on June 10, 2004
Cerebral Cortex 2004 14(11):1256-1265; doi:10.1093/cercor/bhh087
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
© Oxford University Press 2004
Article |
Where Bottom-up Meets Top-down: Neuronal Interactions during Perception and Imagery
1 Wellcome Department of Imaging Neuroscience, Institute of Neurology, 12 Queen Square, London, WC1N 3BG, UK, 2 Institute of Neuroradiology, University of Zurich, 8057 Zurich, Switzerland
Functional magnetic resonance imaging (fMRI) studies have identified category-selective regions in ventral occipito-temporal cortex that respond preferentially to faces and other objects. The extent to which these patterns of activation are modulated by bottom-up or top-down mechanisms is currently unknown. We combined fMRI and dynamic causal modelling to investigate neuronal interactions between occipito-temporal, parietal and frontal regions, during visual perception and visual imagery of faces, houses and chairs. Our results indicate that, during visual perception, category-selective patterns of activation in extrastriate cortex are mediated by content-sensitive forward connections from early visual areas. In contrast, during visual imagery, category-selective activation is mediated by content-sensitive backward connections from prefrontal cortex. Additionally, we report content-unrelated connectivity between parietal cortex and the category-selective regions, during both perception and imagery. Thus, our investigation revealed that neuronal interactions between occipito-temporal, parietal and frontal regions are task- and stimulus-dependent. Sensory representations of faces and objects are mediated by bottom-up mechanisms arising in early visual areas and top-down mechanisms arising in prefrontal cortex, during perception and imagery respectively. Additionally non-selective, top-down processes, originating in superior parietal areas, contribute to the generation of mental images, regardless of their content, and their maintenance in the ‘mind’s eye’.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  M. Esterman and S. Yantis Perceptual Expectation Evokes Category-Selective Cortical Activity Cereb Cortex, September 16, 2009; (2009) bhp188v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. J. M. Kraemer, L. M. Rosenberg, and S. L. Thompson-Schill The Neural Correlates of Visual and Verbal Cognitive Styles J. Neurosci., March 25, 2009; 29(12): 3792 - 3798. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Stokes, R. Thompson, R. Cusack, and J. Duncan Top-Down Activation of Shape-Specific Population Codes in Visual Cortex during Mental Imagery J. Neurosci., February 4, 2009; 29(5): 1565 - 1572. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Ram-Tsur, M. Faust, and A. Z. Zivotofsky Poor Performance on Serial Visual Tasks in Persons With Reading Disabilities: Impaired Working Memory? J Learn Disabil, September 1, 2008; 41(5): 437 - 450. [Abstract] [PDF]
|
|
|
|
|
|
A. T. Sack, C. Jacobs, F. De Martino, N. Staeren, R. Goebel, and E. Formisano Dynamic Premotor-to-Parietal Interactions during Spatial Imagery J. Neurosci., August 20, 2008; 28(34): 8417 - 8429. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Fan, P. R. Hof, K. G. Guise, J. A. Fossella, and M. I. Posner The Functional Integration of the Anterior Cingulate Cortex during Conflict Processing Cereb Cortex, April 1, 2008; 18(4): 796 - 805. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. L. Fairhall and A. Ishai Effective Connectivity within the Distributed Cortical Network for Face Perception Cereb Cortex, October 1, 2007; 17(10): 2400 - 2406. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Gazzaley, J. Rissman, J. Cooney, A. Rutman, T. Seibert, W. Clapp, and M. D'Esposito Functional Interactions between Prefrontal and Visual Association Cortex Contribute to Top-Down Modulation of Visual Processing Cereb Cortex, September 1, 2007; 17(suppl_1): i125 - i135. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Summerfield, T. Egner, M. Greene, E. Koechlin, J. Mangels, and J. Hirsch Predictive codes for forthcoming perception in the frontal cortex. Science, November 24, 2006; 314(5803): 1311 - 1314. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Noppeney, C. J. Price, W. D. Penny, and K. J. Friston Two Distinct Neural Mechanisms for Category-selective Responses Cereb Cortex, March 1, 2006; 16(3): 437 - 445. [Abstract] [Full Text] [PDF]
|
|