Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Supplementary figures
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (24)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Golan, H.
Right arrow Articles by Huleihel, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Golan, H.
Right arrow Articles by Huleihel, M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Cerebral Cortex January 2004; 14:97-105
© Oxford University Press 2004

Involvement of Tumor Necrosis Factor Alpha in Hippocampal Development and Function

H. Golan1,3, T. Levav1,3, A. Mendelsohn1 and M. Huleihel2

1 Department of Developmental Molecular Genetics, Faculty of Health Sciences, Ben Gurion University, Beer-Sheva, Israel, 2 Department of Microbiology and Immunology, Faculty of Health Sciences, Ben Gurion University, Beer-Sheva, Israel, 3 Zlotowski Center for Neuroscience Ben Gurion University, Beer-Sheva, Israel

Tumor necrosis factor alpha (TNF{alpha}) is a cytokine produced mainly by cells of the immune system. It is also expressed by brain neurons and glia. The physiological role of TNF{alpha} in the brain is not yet fully clear. Using TNF{alpha}-deficient mice, we have examined its role in hippocampal development and function. We report here that TNF{alpha} is involved in the regulation of morphological development in the hippocampus. TNF{alpha}-deficient mice exhibited an accelerated maturation of the dentate gyrus region and smaller dendritic trees in CA1 and CA3 regions in young mouse. In addition to its involvement in hippocampal morphogenesis, TNF{alpha} deficiency specifically improved performance of affected mice in behavioral tasks related to spatial memory. Moreover, lack of TNF{alpha} increased the expression of nerve growth factor (NGF), but not brain-derived neurotrophic factor (BDNF), following performance of the learning task. Our results suggest that TNF{alpha} actively influences hippocampal development and function. In adult mice, TNF{alpha} may interfere with memory consolidation, perhaps by regulating NGF levels.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Neurosci.Home page
N. Gavalda, H. Gutierrez, and A. M. Davies
Developmental Regulation of Sensory Neurite Growth by the Tumor Necrosis Factor Superfamily Member LIGHT
J. Neurosci., February 11, 2009; 29(6): 1599 - 1607.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. A. Galic, K. Riazi, J. G. Heida, A. Mouihate, N. M. Fournier, S. J. Spencer, L. E. Kalynchuk, G. C. Teskey, and Q. J. Pittman
Postnatal Inflammation Increases Seizure Susceptibility in Adult Rats
J. Neurosci., July 2, 2008; 28(27): 6904 - 6913.
[Abstract] [Full Text] [PDF]

Home page
 Exp PhysiolHome page
M. Pickering, D. Cumiskey, and J. J O'Connor
Actions of TNF-{alpha} on glutamatergic synaptic transmission in the central nervous system
Exp Physiol, September 1, 2005; 90(5): 663 - 670.
[Abstract] [Full Text] [PDF]

Home page
 NeuroscientistHome page
A. Bessis, D. Bernard, and A. Triller
Tumor Necrosis Factor-{alpha} and Neuronal Development
Neuroscientist, August 1, 2005; 11(4): 277 - 281.
[Abstract] [PDF]

Home page
 J. Neurosci.Home page
D. Stellwagen, E. C. Beattie, J. Y. Seo, and R. C. Malenka
Differential Regulation of AMPA Receptor and GABA Receptor Trafficking by Tumor Necrosis Factor-{alpha}
J. Neurosci., March 23, 2005; 25(12): 3219 - 3228.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.