Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Supplementary data
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (22)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Ioannides, A. A.
Right arrow Articles by Kostopoulos, G. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ioannides, A. A.
Right arrow Articles by Kostopoulos, G. K.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Cerebral Cortex January 2004; 14:56-72
© Oxford University Press 2004

MEG Tomography of Human Cortex and Brainstem Activity in Waking and REM Sleep Saccades

Andreas A. Ioannides1, Maria Corsi-Cabrera2, Peter B.C. Fenwick1, Yolanda del Rio Portilla1,2, Nikos A. Laskaris1, Ara Khurshudyan1, Dionyssios Theofilou1,3, Tadahiko Shibata1, Sunao Uchida4, Tetsuo Nakabayashi4 and George K. Kostopoulos3

1 Laboratory for Human Brain Dynamics, RIKEN Brain Science Institute (BSI), 2-1 Hirosawa, Wako-shi, Saitama, 351-0198, Japan, 2 Facultad de Psicologia, Posgrado, Universidad Nacional Autónoma de México, México City, México, 3 Department of Physiology, Medical School, University of Patras, Patras, Greece, 4 Department of Sleep Disorders Research, Tokyo Institute of Psychiatry, Tokyo 156-8585, Japan

We recorded the magnetoencephalographic (MEG) signal from three subjects before, during and after eye movements cued to a tone, self-paced, awake and during rapid eye movement (REM) sleep. During sleep we recorded the MEG signal throughout the night together with electroencephalographic (EEG) and electromyographic (EMG) channels to construct a hypnogram. While awake, just prior to and during eye movements, the expected well time-locked physiological activations were imaged in pontine regions, with early 3 s priming. Activity in the frontal eye fields (FEF) was identified in the 300 ms before the saccade onset. Visual cortex activation occurred 200 ms after saccades. During REM, compared to the eyes closed awake condition, activity was higher in supplementary motor area (SMA) and lower in inferior parietal and precuneus cortex. Electro-occulographic (EOG) activity just prior to REM saccades correlated with bilateral pontine and FEF activity some 250–400 ms before REM saccade onset, which in turn was preceded 200 ms earlier by reciprocal activation of the pons and FEF. An orbitofrontal-amygdalo-parahippocampal-pontine sequence, possibly related to emotional activation during REM sleep, was identified in the last 100 ms leading to the REM saccade, but not linked to saccade initiation.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 NeuroscientistHome page
A. A. Ioannides
Magnetoencephalography as a Research Tool in Neuroscience: State of the Art
Neuroscientist, December 1, 2006; 12(6): 524 - 544.
[Abstract] [PDF]

Home page
 J. Neurosci.Home page
A. A. Ioannides, P. B. C. Fenwick, and L. Liu
Widely Distributed Magnetoencephalography Spikes Related to the Planning and Execution of Human Saccades
J. Neurosci., August 31, 2005; 25(35): 7950 - 7967.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
E. Limoges, L. Mottron, C. Bolduc, C. Berthiaume, and R. Godbout
Atypical sleep architecture and the autism phenotype
Brain, May 1, 2005; 128(5): 1049 - 1061.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.