Cerebral Cortex January 2004; 14:1-10
© Oxford University Press 2004
Monitoring and the Controlled Processing of Meaning: Distinct Prefrontal Systems
MRC Clinical Sciences Centre, Cyclotron Unit, Hammersmith Hospital, London W12 0NN, UK
Distinct prefrontal regions are specialized for the controlled processing of semantic information. We have dissociated components of this system used in semantic decision-making across different perceptual conditions. Nineteen subjects were presented with auditory word sequences, on which they made semantic or syllabic decisions, while neural activity was measured using PET. Contrasting the semantic with syllabic tasks, there was activation within left rostral prefrontal cortex (RPFC) when the stimuli were presented as clear speech, reducing when the stimuli were presented in acoustically degraded form. In contrast, activation of the right dorsolateral prefrontal cortex (DLPFC) was observed with the degraded stimuli, an effect that inversely correlated with accuracy on the task. We have thus demonstrated two prefrontal systems where activity is differentially modulated by the ‘quality’ of information held in working memory. This dissociation is likely to represent an alteration in the type of cognitive operations employed during task performance, where left RPFC is activated during extensive semantic elaboration and right DLPFC is recruited as the monitoring demands, associated with items held in working memory, increase. The function of these separate systems is integrated during the performance of verbal problem-solving tasks although they are differentially sensitive to stimulus degradation.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  L. A. Miller, R. L. Collins, and T. A. Kent Language and the Modulation of Impulsive Aggression J Neuropsychiatry Clin Neurosci, August 1, 2008; 20(3): 261 - 273. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Raboyeau, X. De Boissezon, N. Marie, S. Balduyck, M. Puel, C. Bezy, J. F. Demonet, and D. Cardebat Right hemisphere activation in recovery from aphasia: Lesion effect or function recruitment? Neurology, January 22, 2008; 70(4): 290 - 298. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Awad, J. E. Warren, S. K. Scott, F. E. Turkheimer, and R. J. S. Wise A Common System for the Comprehension and Production of Narrative Speech J. Neurosci., October 24, 2007; 27(43): 11455 - 11464. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Obleser, R. J. S. Wise, M. Alex Dresner, and S. K. Scott Functional Integration across Brain Regions Improves Speech Perception under Adverse Listening Conditions J. Neurosci., February 28, 2007; 27(9): 2283 - 2289. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. J. Sharp, S. K. Scott, M. A. Mehta, and R. J.S. Wise The Neural Correlates of Declining Performance with Age: Evidence for Age-Related Changes in Cognitive Control Cereb Cortex, December 1, 2006; 16(12): 1739 - 1749. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Vigliocco, J. Warren, S. Siri, J. Arciuli, S. Scott, and R. Wise The Role of Semantics and Grammatical Class in the Neural Representation of Words Cereb Cortex, December 1, 2006; 16(12): 1790 - 1796. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. T. Crinion, E. A. Warburton, M. A. Lambon-Ralph, D. Howard, and R. J.S. Wise Listening to Narrative Speech after Aphasic Stroke: the Role of the Left Anterior Temporal Lobe Cereb Cortex, August 1, 2006; 16(8): 1116 - 1125. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Spitsyna, J. E. Warren, S. K. Scott, F. E. Turkheimer, and R. J. S. Wise Converging language streams in the human temporal lobe. J. Neurosci., July 12, 2006; 26(28): 7328 - 7336. [Abstract] [Full Text] [PDF]
|
|