Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (38)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by López-Bendito, G.
Right arrow Articles by Molnár, Z.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by López-Bendito, G.
Right arrow Articles by Molnár, Z.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Cerebral Cortex, Vol. 13, No. 9, 932-942, September 2003
© 2003 Oxford University Press

Blockade of GABAB Receptors Alters the Tangential Migration of Cortical Neurons

Guillermina López-Bendito, Rafael Luján1, Ryuichi Shigemoto2, Paul Ganter3, Ole Paulsen3 and Zoltán Molnár

Department of Human Anatomy & Genetics, University of Oxford, Oxford OX1 3QX, UK, , 1 Centro Regional de Investigaciones Biomédicas, Facultad de Medicina, Universidad de Castilla, La Mancha, Campus Biosanitario, 02071 Albacete, Spain, , 2 Division of Cerebral Structure, National Institute for Physiological Sciences, Myodaiji, Okazaki 444-8585, CREST Japan Science and Technology Corporation, Japan and , 3 University Laboratory of Physiology, Parks Road, Oxford OX1 3PT, UK

To better understand the role of neurotransmitter receptors in neuronal differentiation and maturation a detailed knowledge of their identity, location and function in the plasma membrane of specific neuronal populations during development is required. Combining pre-embedding immunocytochemistry with cell tracking in embryonic brain slice cultures we show that virtually all neurons (~98%) migrating through the lower intermediate zone (LIZ) on their way from the medial ganglionic eminence to the cerebral cortex, express GABABR1. Blockade of GABABRs with a specific antagonist, CGP52432, resulted in a concentration-dependent accumulation of these tangentially migrating neurons in the ventricular/sub-ventricular zones (VZ/SVZ) of the cortex and fewer cells were observed in the cortical plate/marginal zone (CP/MZ) and LIZ. Moreover, they had significantly shorter leading processes compared with similar migrating cells in control slices. Electrophysiological recording in LIZ and CP cells revealed no direct effect of either CGP52432 or the GABABR agonist, baclofen, on resting membrane properties suggesting that the effect of CGP52432 on migration might be mediated through a metabotropic action or the regulation of release of factors controlling migration. These results suggest that GABABRs have an important modulatory role in the migration of cortical interneurons.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Cereb CortexHome page
S. Poluch, B. Jablonska, and S. L. Juliano
Alteration of Interneuron Migration in a Ferret Model of Cortical Dysplasia
Cereb Cortex, January 1, 2008; 18(1): 78 - 92.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
Y. Ben-Ari, J.-L. Gaiarsa, R. Tyzio, and R. Khazipov
GABA: A Pioneer Transmitter That Excites Immature Neurons and Generates Primitive Oscillations
Physiol Rev, October 1, 2007; 87(4): 1215 - 1284.
[Abstract] [Full Text] [PDF]

Home page
 NeuroscientistHome page
J.-B. Manent and A. Represa
Neurotransmitters and Brain Maturation: Early Paracrine Actions of GABA and Glutamate Modulate Neuronal Migration
Neuroscientist, June 1, 2007; 13(3): 268 - 279.
[Abstract] [PDF]

Home page
 Cereb CortexHome page
N. Heck, W. Kilb, P. Reiprich, H. Kubota, T. Furukawa, A. Fukuda, and H. J. Luhmann
GABA-A Receptors Regulate Neocortical Neuronal Migration In Vitro and In Vivo
Cereb Cortex, January 1, 2007; 17(1): 138 - 148.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
V. C. Cuzon, P. W. Yeh, Q. Cheng, and H. H. Yeh
Ambient GABA Promotes Cortical Entry of Tangentially Migrating Cells Derived from the Medial Ganglionic Eminence
Cereb Cortex, October 1, 2006; 16(10): 1377 - 1388.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J.-B. Manent, I. Jorquera, Y. Ben-Ari, L. Aniksztejn, and A. Represa
Glutamate acting on AMPA but not NMDA receptors modulates the migration of hippocampal interneurons.
J. Neurosci., May 31, 2006; 26(22): 5901 - 5909.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J.-B. Manent, M. Demarque, I. Jorquera, C. Pellegrino, Y. Ben-Ari, L. Aniksztejn, and A. Represa
A Noncanonical Release of GABA and Glutamate Modulates Neuronal Migration
J. Neurosci., May 11, 2005; 25(19): 4755 - 4765.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
G. Lopez-Bendito, K. Sturgess, F. Erdelyi, G. Szabo, Z. Molnar, and O. Paulsen
Preferential Origin and Layer Destination of GAD65-GFP Cortical Interneurons
Cereb Cortex, October 1, 2004; 14(10): 1122 - 1133.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
D. Tanaka, Y. Nakaya, Y. Yanagawa, K. Obata, and F. Murakami
Multimodal tangential migration of neocortical GABAergic neurons independent of GPI-anchored proteins
Development, December 1, 2003; 130(23): 5803 - 5813.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.