Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (45)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Levitt, J. G.
Right arrow Articles by Toga, A. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Levitt, J. G.
Right arrow Articles by Toga, A. W.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Cerebral Cortex, Vol. 13, No. 7, 728-735, July 2003
© 2003 Oxford University Press

Cortical Sulcal Maps in Autism

Jennifer G. Levitt, Rebecca E. Blanton1, Susan Smalley, P.M. Thompson1, Donald Guthrie, James T. McCracken, Tania Sadoun1, Laura Heinichen and Arthur W. Toga1

Department of Psychiatry, UCLA Neuropsychiatric Institute, Los Angeles, CA 90024 and , 1 Laboratory of Neuro Imaging, UCLA, Los Angeles, CA 90024, USA

This study presents the first three-dimensional mapping of cortical sulcal patterns in autism, a pervasive developmental disorder, the underlying neurobiology of which remains unknown. High-resolution T1-weighted MRI scans were acquired in 21 autistic (age 10.7 ± 3.1 years) and 20 normal control (age 11.3 ± 2.9) children and adolescents. Using parametric mesh-based analytic techniques, we created three-dimensional models of the cerebral cortex and detailed maps of 22 major sulci in stereotaxic space. These average maps revealed anatomic shifting of major sulci primarily in frontal and temporal areas. Specifically, we found anterior and superior shifting of the superior frontal sulci bilaterally (P ≤ 0.0003), anterior shifting of the right Sylvian fissure (P = 0.0002), the superior temporal sulcus (P = 0.0006 right, P = 0.02 left) and the left inferior frontal sulcus (P ≤ 0.002) in the autistic group relative to the normal group. Less significant sulcal shifts occurred in the intraparietal and collateral sulci. These findings may indicate delayed maturation in autistic subjects in these brain regions involved in functions including working memory, emotion processing, language and eye gaze.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Cereb CortexHome page
S. Li, Y. Han, D. Wang, H. Yang, Y. Fan, Y. Lv, H. Tang, Q. Gong, Y. Zang, and Y. He
Mapping Surface Variability of the Central Sulcus in Musicians
Cereb Cortex, May 11, 2009; (2009) bhp074v1.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
S. H. Mostofsky, S. K. Powell, D. J. Simmonds, M. C. Goldberg, B. Caffo, and J. J. Pekar
Decreased connectivity and cerebellar activity in autism during motor task performance
Brain, April 23, 2009; (2009) awp088v1.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
C. Limperopoulos, H. Bassan, N. R. Sullivan, J. S. Soul, R. L. Robertson Jr, M. Moore, S. A. Ringer, J. J. Volpe, and A. J. du Plessis
Positive Screening for Autism in Ex-preterm Infants: Prevalence and Risk Factors
Pediatrics, April 1, 2008; 121(4): 758 - 765.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
C. P. Johnson, S. M. Myers, and and the Council on Children With Disabilities
Identification and Evaluation of Children With Autism Spectrum Disorders
Pediatrics, November 1, 2007; 120(5): 1183 - 1215.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
C. W. Nordahl, D. Dierker, I. Mostafavi, C. M. Schumann, S. M. Rivera, D. G. Amaral, and D. C. Van Essen
Cortical Folding Abnormalities in Autism Revealed by Surface-Based Morphometry
J. Neurosci., October 24, 2007; 27(43): 11725 - 11735.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
M. Behrmann, G. Avidan, F. Gao, and S. Black
Structural Imaging Reveals Anatomical Alterations in Inferotemporal Cortex in Congenital Prosopagnosia
Cereb Cortex, October 1, 2007; 17(10): 2354 - 2363.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
N. Hadjikhani, R. M. Joseph, J. Snyder, and H. Tager-Flusberg
Anatomical Differences in the Mirror Neuron System and Social Cognition Network in Autism
Cereb Cortex, September 1, 2006; 16(9): 1276 - 1282.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
H. Petropoulos, S. D. Friedman, D.W.W. Shaw, A. A. Artru, G. Dawson, and S. R. Dager
Gray matter abnormalities in autism spectrum disorder revealed by T2 relaxation.
Neurology, August 22, 2006; 67(4): 632 - 636.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
K. A. Pelphrey, J. P. Morris, and G. McCarthy
Neural basis of eye gaze processing deficits in autism
Brain, May 1, 2005; 128(5): 1038 - 1048.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.