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Cerebral Cortex December 2003; 13:1271-1275
© Oxford University Press 2003

Feature Article

Estrogen and the Aging Hippocampal Synapse

Michelle M. Adams1,2 and John H. Morrison1

1 Kastor Neurobiology of Aging Laboratory, Fishberg Research Center for Neurobiology, and Henry L. Schwartz Department of Geriatrics and Adult Development, Mount Sinai School of Medicine, New York, NY 10029, USA

2 Present address: Department of Neuroscience, Howard Hughes Medical Institute, Brown University Box 1953, Providence, RI 02912, USA

The ramifications of endocrine and neural senescence converge in the hippocampus, particularly with respect to glutamatergic synapses. In this review, we will focus on current literature suggesting that potential synaptic alterations induced by estrogen in the hippocampus are mediated through interactions between ER-{alpha} and NMDA receptors. In addition, we will examine the data suggesting that these interactions may be uncoupled with aging. These studies demonstrate that while estrogen helps retain a youthful synaptic phenotype by some measures, the aged synapse may differ from the young synapse in several key respects that impact plasticity in general, and endocrine influences on the synapse, in particular.


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