Cerebral Cortex November 2003; 13:1257-1269
© Oxford University Press 2003
A Role for Neural Integrators in Perceptual Decision Making
Howard Hughes Medical Institute, Department of Physiology and Biophysics, and National Primate Research Center, University of Washington, Seattle, WA 98195-7290, USA
Decisions based on uncertain information may benefit from an accumulation of information over time. We asked whether such an accumulation process may underlie decisions about the direction of motion in a random dot kinetogram. To address this question we developed a computational model of the decision process using ensembles of neurons whose spiking activity mimics neurons recorded in the extrastriate visual cortex (area MT or V5) and a sensorimotor association area of the parietal lobe (area LIP). The model instantiates the hypothesis that neurons in sensorimotor association areas compute the time integral of sensory signals from the visual cortex, construed as evidence for or against a proposition, and that the decision is made when the integrated evidence reaches a threshold. The model explains a variety of behavioral and physiological measurements obtained from monkeys.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  M. Nikitchenko and A. Koulakov Neural Integrator: A Sandpile Model Neural Comput., October 1, 2008; 20(10): 2379 - 2417. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Kim and M. A. Basso Saccade Target Selection in the Superior Colliculus: A Signal Detection Theory Approach J. Neurosci., March 19, 2008; 28(12): 2991 - 3007. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Kiani, T. D. Hanks, and M. N. Shadlen Bounded Integration in Parietal Cortex Underlies Decisions Even When Viewing Duration Is Dictated by the Environment J. Neurosci., March 19, 2008; 28(12): 3017 - 3029. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Chen, W. S. Geisler, and E. Seidemann Optimal Temporal Decoding of Neural Population Responses in a Reaction-Time Visual Detection Task J Neurophysiol, March 1, 2008; 99(3): 1366 - 1379. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Y. Masse and E. P. Cook The Effect of Middle Temporal Spike Phase on Sensory Encoding and Correlates with Behavior during a Motion-Detection Task J. Neurosci., February 6, 2008; 28(6): 1343 - 1355. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. T. Serences and G. M. Boynton The Representation of Behavioral Choice for Motion in Human Visual Cortex J. Neurosci., November 21, 2007; 27(47): 12893 - 12899. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. W. Battaglia and P. R. Schrater Humans Trade Off Viewing Time and Movement Duration to Improve Visuomotor Accuracy in a Fast Reaching Task J. Neurosci., June 27, 2007; 27(26): 6984 - 6994. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. N. Tobler and T. Kalenscher Awfully Afraid? Dissociating Decision- from Motor- and Sensory-Related Brain Activation during Perceptual Choices J. Neurosci., June 6, 2007; 27(23): 6081 - 6082. [Full Text] [PDF]
|
|
|
|
|
|
H. Okamoto, Y. Isomura, M. Takada, and T. Fukai Temporal Integration by Stochastic Recurrent Network Dynamics With Bimodal Neurons J Neurophysiol, June 1, 2007; 97(6): 3859 - 3867. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Deneve, J.-R. Duhamel, and A. Pouget Optimal Sensorimotor Integration in Recurrent Cortical Networks: A Neural Implementation of Kalman Filters J. Neurosci., May 23, 2007; 27(21): 5744 - 5756. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. D. Hayes and W. H. Merigan Mechanisms of Sensitivity Loss due to Visual Cortex Lesions in Humans and Macaques Cereb Cortex, May 1, 2007; 17(5): 1117 - 1128. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Ratcliff and G. McKoon The Diffusion Decision Model: Theory and Data for Two-Choice Decision Tasks Neural Comput., April 1, 2007; 20(4): 873 - 922. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Ratcliff, Y. T. Hasegawa, R. P. Hasegawa, P. L. Smith, and M. A. Segraves Dual Diffusion Model for Single-Cell Recording Data From the Superior Colliculus in a Brightness-Discrimination Task J Neurophysiol, February 1, 2007; 97(2): 1756 - 1774. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Celikel and B. Sakmann Sensory integration across space and in time for decision making in the somatosensory system of rodents PNAS, January 23, 2007; 104(4): 1395 - 1400. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Deneve Bayesian Spiking Neurons I: Inference Neural Comput., January 1, 2007; 20(1): 91 - 117. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Preuschhof, H. R. Heekeren, B. Taskin, T. Schubert, and A. Villringer Neural Correlates of Vibrotactile Working Memory in the Human Brain J. Neurosci., December 20, 2006; 26(51): 13231 - 13239. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Zaksas and T. Pasternak Directional Signals in the Prefrontal Cortex and in Area MT during a Working Memory for Visual Motion Task. J. Neurosci., November 8, 2006; 26(45): 11726 - 11742. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Cisek Integrated neural processes for defining potential actions and deciding between them: a computational model. J. Neurosci., September 20, 2006; 26(38): 9761 - 9770. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. G. Philiastides, R. Ratcliff, and P. Sajda Neural Representation of Task Difficulty and Decision Making during Perceptual Categorization: A Timing Diagram. J. Neurosci., August 30, 2006; 26(35): 8965 - 8975. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Li, B. Kim, and M. A. Basso Transient Pauses in Delay-Period Activity of Superior Colliculus Neurons J Neurophysiol, April 1, 2006; 95(4): 2252 - 2264. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. G. Philiastides and P. Sajda Temporal Characterization of the Neural Correlates of Perceptual Decision Making in the Human Brain Cereb Cortex, April 1, 2006; 16(4): 509 - 518. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K.-F. Wong and X.-J. Wang A Recurrent Network Mechanism of Time Integration in Perceptual Decisions J. Neurosci., January 25, 2006; 26(4): 1314 - 1328. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. C. Huk and M. N. Shadlen Neural Activity in Macaque Parietal Cortex Reflects Temporal Integration of Visual Motion Signals during Perceptual Decision Making J. Neurosci., November 9, 2005; 25(45): 10420 - 10436. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. J. H. Ludwig, I. D. Gilchrist, E. McSorley, and R. J. Baddeley The Temporal Impulse Response Underlying Saccadic Decisions J. Neurosci., October 26, 2005; 25(43): 9907 - 9912. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. C. Clayton, J. Rajkowski, J. D. Cohen, and G. Aston-Jones Phasic Activation of Monkey Locus Ceruleus Neurons by Simple Decisions in a Forced-Choice Task J. Neurosci., November 3, 2004; 24(44): 9914 - 9920. [Abstract] [Full Text] [PDF]
|
|