Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (34)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Otani, S.
Right arrow Articles by Crepel, F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Otani, S.
Right arrow Articles by Crepel, F.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Cerebral Cortex November 2003; 13:1251-1256
© Oxford University Press 2003

Dopaminergic Modulation of Long-term Synaptic Plasticity in Rat Prefrontal Neurons

Satoru Otani1, Hérve Daniel1, Marie-Paule Roisin2 and Francis Crepel1

1 Neurobiologie des Processus Adaptatifs, Université Paris VI, France, 2 Laboratoire de Signalisation Cellulaire et Parasites, Hôpital Cochin, Paris, France

In rat prefrontal cortex (the prelimbic area of medial frontal cortex), the induction of long-term depression (LTD) and long-term potentiation (LTP) of glutamatergic synapses is powerfully modulated by dopamine. The presence of dopamine in the bathing medium facilitates LTD in slice preparations, whereas in the anesthetized intact brain, dopamine released from dopaminergic axon terminals in the prefrontal cortex facilitates LTP. Dopaminergic facilitation of LTD is at least partly achieved by postsynaptic biochemical mechanisms in which enzymatic processes triggered by dopamine receptor activation cooperate with those triggered by glutamate metabotropic receptor activation. Evidence suggests that dopamine facilitates LTP also in the slice condition. In this case, dopamine receptors must be pre-stimulated (‘primed’) before the application of high-frequency stimuli in the presence of dopamine. This procedure may mimic baseline stimulation of dopamine receptors that occurs under physiological conditions.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Neurosci.Home page
G. Akopian, C. Crawford, M. F. Beal, M. Cappelletti, M. W. Jakowec, G. M. Petzinger, L. Zheng, S. L. Gheorghe, C. M. Reichel, R. Chow, et al.
Decreased Striatal Dopamine Release Underlies Increased Expression of Long-Term Synaptic Potentiation at Corticostriatal Synapses 24 h after 3-Nitropropionic-Acid-Induced Chemical Hypoxia
J. Neurosci., September 17, 2008; 28(38): 9585 - 9597.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
H. Schicknick, B. H. Schott, E. Budinger, K.-H. Smalla, A. Riedel, C. I. Seidenbecher, H. Scheich, E. D. Gundelfinger, and W. Tischmeyer
Dopaminergic Modulation of Auditory Cortex-Dependent Memory Consolidation through mTOR
Cereb Cortex, March 6, 2008; (2008) bhn026v2.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
E. M. Izhikevich
Solving the Distal Reward Problem through Linkage of STDP and Dopamine Signaling
Cereb Cortex, October 1, 2007; 17(10): 2443 - 2452.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
J. A. J. van der Meulen, R. N. J. M. A. Joosten, J. P. C. de Bruin, and M. G. P. Feenstra
Dopamine and Noradrenaline Efflux in the Medial Prefrontal Cortex During Serial Reversals and Extinction of Instrumental Goal-Directed Behavior
Cereb Cortex, June 1, 2007; 17(6): 1444 - 1453.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
W. J. Kargo, B. Szatmary, and D. A. Nitz
Adaptation of Prefrontal Cortical Firing Patterns and Their Fidelity to Changes in Action-Reward Contingencies
J. Neurosci., March 28, 2007; 27(13): 3548 - 3559.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
B. G. Mockett, D. Guevremont, J. M. Williams, and W. C. Abraham
Dopamine D1/D5 Receptor Activation Reverses NMDA Receptor-Dependent Long-Term Depression in Rat Hippocampus
J. Neurosci., March 14, 2007; 27(11): 2918 - 2926.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
L. Chen, J. D. Bohanick, M. Nishihara, J. K. Seamans, and C. R. Yang
Dopamine D1/5 Receptor-Mediated Long-Term Potentiation of Intrinsic Excitability in Rat Prefrontal Cortical Neurons: Ca2+-Dependent Intracellular Signaling
J Neurophysiol, March 1, 2007; 97(3): 2448 - 2464.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. Soltani and X.-J. Wang
A biophysically based neural model of matching law behavior: melioration by stochastic synapses.
J. Neurosci., April 5, 2006; 26(14): 3731 - 3744.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
F. Morgante, A. J. Espay, C. Gunraj, A. E. Lang, and R. Chen
Motor cortex plasticity in Parkinson's disease and levodopa-induced dyskinesias
Brain, April 1, 2006; 129(4): 1059 - 1069.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
X. Sun, Y. Zhao, and M. E. Wolf
Dopamine Receptor Stimulation Modulates AMPA Receptor Synaptic Insertion in Prefrontal Cortex Neurons
J. Neurosci., August 10, 2005; 25(32): 7342 - 7351.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
S. T. Papadeas, B. L. Blake, D. J. Knapp, and G. R. Breese
Sustained Extracellular Signal-Regulated Kinase 1/2 Phosphorylation in Neonate 6-Hydroxydopamine-Lesioned Rats after Repeated D1-Dopamine Receptor Agonist Administration: Implications for NMDA Receptor Involvement
J. Neurosci., June 30, 2004; 24(26): 5863 - 5876.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.