Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (30)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Brunel, N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Brunel, N.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Cerebral Cortex November 2003; 13:1151-1161
© Oxford University Press 2003

Dynamics and Plasticity of Stimulus-selective Persistent Activity in Cortical Network Models

Nicolas Brunel

CNRS, NPSM, Université Paris René Descartes, 45 rue des Saints Pères, 75270 Paris Cedex 06, France

Persistent neuronal activity is widespread in many areas of the cerebral cortex of monkeys performing cognitive tasks with a working memory component. Modeling studies have helped understanding of the conditions under which persistent activity can be sustained in cortical circuits. Here, we first review several basic models of persistent activity, including bistable models with excitation only and multistable models for working memory of a discrete set of pictures or objects with structured excitation and global inhibition. In many experiments, persistent activity has been shown to be subject to changes due to associative learning. In cortical network models, Hebbian learning shapes the synaptic structure and, in turn, the properties of persistent activity when pictures are associated together in the course of a task. It is shown how the theoretical models can reproduce basic experimental findings of neurophysiological recordings from inferior temporal and perirhinal cortices obtained using the following experimental protocols: (i) the pair-associate task; (ii) the pair-associate task with color switch; and (iii) the delay match to sample task with a fixed sequence of samples.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 ScienceHome page
G. Mongillo, O. Barak, and M. Tsodyks
Synaptic Theory of Working Memory
Science, March 14, 2008; 319(5869): 1543 - 1546.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
R. D. Hayes and W. H. Merigan
Mechanisms of Sensitivity Loss due to Visual Cortex Lesions in Humans and Macaques
Cereb Cortex, May 1, 2007; 17(5): 1117 - 1128.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
D. Zaksas and T. Pasternak
Directional Signals in the Prefrontal Cortex and in Area MT during a Working Memory for Visual Motion Task.
J. Neurosci., November 8, 2006; 26(45): 11726 - 11742.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
T. Gisiger, M. Kerszberg, and J.-P. Changeux
Acquisition and Performance of Delayed-response Tasks: a Neural Network Model
Cereb Cortex, May 1, 2005; 15(5): 489 - 506.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
C. D. Paspalas and P. S. Goldman-Rakic
Presynaptic D1 Dopamine Receptors in Primate Prefrontal Cortex: Target-Specific Expression in the Glutamatergic Synapse
J. Neurosci., February 2, 2005; 25(5): 1260 - 1267.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
D. J. Amit and G. Mongillo
Selective Delay Activity in the Cortex: Phenomena and Interpretation
Cereb Cortex, November 1, 2003; 13(11): 1139 - 1150.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.