Cerebral Cortex, Vol. 12, No. 9, 893-899,
September 2002
© 2002 Oxford University Press
FEATURE ARTICLE |
Homeostatic Maintenance of Neuronal Excitability by Burst Discharges In Vivo
Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, 197 University Avenue, Newark, NJ 07102, USA
Address correspondence to: György Buzsáki, Center for Molecular and Behavioral Neuroscience, Rutgers University, 197 University Avenue, Newark, NJ 07102, USA. Email: Buzsaki{at}axon.rutgers.edu.
Information in neuronal networks is thought to be represented by the rate of discharge and the temporal relationship between the discharging neurons. The discharge frequency of neurons is affected by their afferents and intrinsic properties, and shows great individual variability. The temporal coordination of neurons is greatly facilitated by network oscillations. In the hippocampus, population synchrony fluctuates during theta and gamma oscillations (10–100 ms scale) and can increase almost 10-fold during sharp wave bursts. Despite these large changes in excitability in the sub-second scale, longer-term (minute-scale) firing rates of individual neurons are relatively constant in an unchanging environment. As a result, mean hippocampal output remains stable over time. To understand the mechanisms responsible for this homeostasis, we address the following issues: (i) Can firing rates of single cells be modified? (ii) Once modified, what mechanism(s) can maintain the changes? We show that firing rates of hippocampal pyramidal cells can be altered in a novel environment and by Hebbian pairing of physiological input patterns with postsynaptic burst discharge. We also illustrate a competition between single spikes and the occurrence of spike bursts. Since spike-inducing (suprathreshold) inputs decrease the ability of strong (‘teaching’) inputs to induce a burst discharge, we propose that the single spike versus burst competition presents a homeostatic regulatory mechanism to maintain synaptic strength and, consequently, firing rate in pyramidal cells.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  J. J. Zhu Activity Level-Dependent Synapse-Specific AMPA Receptor Trafficking Regulates Transmission Kinetics J. Neurosci., May 13, 2009; 29(19): 6320 - 6335. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. C. Frey, R. Sprengel, and T. Nevian Activity Pattern-Dependent Long-Term Potentiation in Neocortex and Hippocampus of GluA1 (GluR-A) Subunit-Deficient Mice J. Neurosci., April 29, 2009; 29(17): 5587 - 5596. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Tsanov and D. Manahan-Vaughan Synaptic Plasticity from Visual Cortex to Hippocampus: Systems Integration in Spatial Information Processing Neuroscientist, December 1, 2008; 14(6): 584 - 597. [Abstract] [PDF]
|
|
|
|
|
|
A. A. Fenton, H.-Y. Kao, S. A. Neymotin, A. Olypher, Y. Vayntrub, W. W. Lytton, and N. Ludvig Unmasking the CA1 Ensemble Place Code by Exposures to Small and Large Environments: More Place Cells and Multiple, Irregularly Arranged, and Expanded Place Fields in the Larger Space J. Neurosci., October 29, 2008; 28(44): 11250 - 11262. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. J. Sjostrom, E. A. Rancz, A. Roth, and M. Hausser Dendritic Excitability and Synaptic Plasticity Physiol Rev, April 1, 2008; 88(2): 769 - 840. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Rinaldi, G. Silberberg, and H. Markram Hyperconnectivity of Local Neocortical Microcircuitry Induced by Prenatal Exposure to Valproic Acid Cereb Cortex, April 1, 2008; 18(4): 763 - 770. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. V. Olypher and R. L. Calabrese Using Constraints on Neuronal Activity to Reveal Compensatory Changes in Neuronal Parameters J Neurophysiol, December 1, 2007; 98(6): 3749 - 3758. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Ford, J. H. Krystal, and D. H. Mathalon Neural Synchrony in Schizophrenia: From Networks to New Treatments Schizophr Bull, July 1, 2007; 33(4): 848 - 852. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Bai, X. Huang, Q. Yang, and J.-Y. Wu Spatiotemporal Patterns of an Evoked Network Oscillation in Neocortical Slices: Coupled Local Oscillators J Neurophysiol, November 1, 2006; 96(5): 2528 - 2538. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. M. Wittenberg and S. S.-H. Wang Malleability of spike-timing-dependent plasticity at the CA3-CA1 synapse. J. Neurosci., June 14, 2006; 26(24): 6610 - 6617. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. V. Olypher, D. Klement, and A. A. Fenton Cognitive Disorganization in Hippocampus: A Physiological Model of the Disorganization in Psychosis J. Neurosci., January 4, 2006; 26(1): 158 - 168. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Anglada-Figueroa and G. J. Quirk Lesions of the Basal Amygdala Block Expression of Conditioned Fear But Not Extinction J. Neurosci., October 19, 2005; 25(42): 9680 - 9685. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Qin, Y. Zhu, J. P. Baumgart, R. L. Stornetta, K. Seidenman, V. Mack, L. van Aelst, and J. J. Zhu State-dependent Ras signaling and AMPA receptor trafficking Genes & Dev., September 1, 2005; 19(17): 2000 - 2015. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Otsu and T. H. Murphy Optical Postsynaptic Measurement of Vesicle Release Rates for Hippocampal Synapses Undergoing Asynchronous Release during Train Stimulation J. Neurosci., October 13, 2004; 24(41): 9076 - 9086. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Durstewitz Self-Organizing Neural Integrator Predicts Interval Times through Climbing Activity J. Neurosci., June 15, 2003; 23(12): 5342 - 5353. [Abstract] [Full Text] [PDF]
|
|